CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036650
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Catenin alpha-1 
Protein Synonyms/Alias
  
Gene Name
 CTNNA1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
108LAAKPQSKLAQENMDubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 128 AA 
Protein Sequence
MTKKTRDLRR QLRKAVMDHV SDSFLETNVP LLVLIEAAKN GNEKEVKEYA QVFREHANKL 60
IEVANLACSI SNNEEGVKLV RMSASQLEAL CPQVINAALA LAAKPQSKLA QENMDLFKEQ 120
WEKQVRVL 128 
Gene Ontology
 GO:0001669; C:acrosomal vesicle; IEA:Compara.
 GO:0015629; C:actin cytoskeleton; IEA:InterPro.
 GO:0014704; C:intercalated disc; IEA:Compara.
 GO:0030027; C:lamellipodium; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0005915; C:zonula adherens; IEA:Compara.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0007568; P:aging; IEA:Compara.
 GO:0043297; P:apical junction assembly; IEA:Compara.
 GO:0031103; P:axon regeneration; IEA:Compara.
 GO:0007155; P:cell adhesion; IEA:InterPro.
 GO:0007163; P:establishment or maintenance of cell polarity; IEA:Compara.
 GO:0016264; P:gap junction assembly; IEA:Compara.
 GO:0008584; P:male gonad development; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0007406; P:negative regulation of neuroblast proliferation; IEA:Compara.
 GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Compara.
 GO:0001541; P:ovarian follicle development; IEA:Compara.
 GO:0045880; P:positive regulation of smoothened signaling pathway; IEA:Compara.
 GO:0051291; P:protein heterooligomerization; IEA:Compara.
 GO:0043627; P:response to estrogen stimulus; IEA:Compara. 
Interpro
 IPR001033; Alpha_catenin.
 IPR006077; Vinculin/catenin. 
Pfam
 PF01044; Vinculin 
SMART
  
PROSITE
  
PRINTS
 PR00805; ALPHACATENIN.