CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023938
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sorting nexin-13 
Protein Synonyms/Alias
 RGS domain- and PHOX domain-containing protein; RGS-PX1 
Gene Name
 SNX13 
Gene Synonyms/Alias
 KIAA0713 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
149IQFATRSKEIDWQPYubiquitination[1]
331GDDINTIKNQINSLLubiquitination[2]
453YEQYLSEKASPRVTVubiquitination[1, 2]
654RDFLEKRKKDLNAYLubiquitination[2]
655DFLEKRKKDLNAYLQubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 May be involved in several stages of intracellular trafficking. May play a role in endosome homeostasis (By similarity). Acts as a GAP for Galphas. 
Sequence Annotation
 DOMAIN 97 284 PXA.
 DOMAIN 373 496 RGS.
 DOMAIN 570 691 PX.
 BINDING 612 612 Phosphatidylinositol 3-phosphate (By
 BINDING 614 614 Phosphatidylinositol 3-phosphate; via
 BINDING 639 639 Phosphatidylinositol 3-phosphate (By
 BINDING 653 653 Phosphatidylinositol 3-phosphate (By  
Keyword
 Alternative splicing; Complete proteome; Endosome; Lipid-binding; Membrane; Polymorphism; Protein transport; Reference proteome; Signal transduction inhibitor; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 968 AA 
Protein Sequence
MLTEASLSIW GWGSLGIVLF LITFGPFVIF YLTFYILCFV GGGLVVTLLF GKTNSEKYLE 60
QCEHSFLPPT SPGVPKCLEE MKREARTIKI DRRLTGANII DEPLQQVIQF SLRDYVQYWY 120
YTLSDDESFL LEIRQTLQNA LIQFATRSKE IDWQPYFTTR IVDDFGTHLR VFRKAQQKIT 180
EKDDQVKGTA EDLVDTFFEV EVEMEKEVCR DLVCTSPKDE EGFLRDLCEV LLYLLLPPGD 240
FQNKIMRYFV REILARGILL PLINQLSDPD YINQYVIWMI RDSNCNYEAF MNIIKLSDNI 300
GELEAVRDKA AEELQYLRSL DTAGDDINTI KNQINSLLFV KKVCDSRIQR LQSGKEINTV 360
KLAANFGKLC TVPLDSILVD NVALQFFMDY MQQTGGQAHL FFWMTVEGYR VTAQQQLEVL 420
LSRQRDGKHQ TNQTKGLLRA AAVGIYEQYL SEKASPRVTV DDYLVAKLAD TLNHEDPTPE 480
IFDDIQRKVY ELMLRDERFY PSFRQNALYV RMLAELDMLK DPSFRGSDDG DGESFNGSPT 540
GSINLSLDDL SNVSSDDSVQ LHAYISDTVY ADYDPYAVAG VCNDHGKTYA LYAITVHRRN 600
LNSEEMWKTY RRYSDFHDFH MRITEQFESL SSILKLPGKK TFNNMDRDFL EKRKKDLNAY 660
LQLLLAPEMM KASPALAHYV YDFLENKAYS KGKGDFARKM DTFVNPLRNS MRNVSNAVKS 720
LPDSLAEGMT KMSDNMGKMS ERLGQDIKQS FFKVPPLIPK TDSDPEHRRV SAQLDDNVDD 780
NIPLRVMLLL MDEVFDLKER NQWLRRNIKN LLQQLIRATY GDTINRKIVD HVDWMTSPEQ 840
VADSVKRFRD AFWPNGILAE AVPCRDKSIR MRTRVAGKTK LLAIMPDELK HIIGAETTRK 900
GILRVFEMFQ HNQLNRRMVY VFLEGFLETL FPQYKFRELF NKLHSRSKQM QKYKQKLQTT 960
QAPSLQKR 968 
Gene Ontology
 GO:0005769; C:early endosome; IDA:UniProtKB.
 GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
 GO:0035091; F:phosphatidylinositol binding; IDA:UniProtKB.
 GO:0007154; P:cell communication; IEA:InterPro.
 GO:0006886; P:intracellular protein transport; IMP:UniProtKB.
 GO:0043547; P:positive regulation of GTPase activity; IDA:UniProtKB.
 GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro. 
Interpro
 IPR001683; Phox.
 IPR003114; Phox_assoc.
 IPR013996; PX_assoc_Snx13.
 IPR000342; Regulat_G_prot_signal.
 IPR016137; Regulat_G_prot_signal_superfam.
 IPR013937; Sorting_nexin_C. 
Pfam
 PF08628; Nexin_C
 PF00787; PX
 PF02194; PXA
 PF00615; RGS 
SMART
 SM00312; PX
 SM00313; PXA
 SM00315; RGS 
PROSITE
 PS50195; PX
 PS51207; PXA
 PS50132; RGS 
PRINTS