UniProt Accession

 APOA1_RAT; P04639; O08877; O09054; Q5EBB2 

Genbank Protein ID

 M00001; X00558; J02597; U79576; U79577; U79578; BC089820 

Genbank Nucleotide ID

 AAA40749.1; CAA25224.1; AAA40745.1; AAB58428.1; AAB58429.1; AAB58430.1; AAH89820.1 

Protein Name

 Apolipoprotein A-I 

Protein Synonyms/Alias

 Apo-AI; ApoA-I; Apolipoprotein A1 

Gene Name

 Apoa1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
35	QSQWDRVKDFATVYV	acetylation	[1]
111	WLRNEMNKDLENVKQ	acetylation	[1]
117	NKDLENVKQKMQPHL	acetylation	[1]
119	DLENVKQKMQPHLDE	acetylation	[1]
141	EVEAYRQKLEPLGTE	acetylation	[1]
151	PLGTELHKNAKEMQR	acetylation	[1]
154	TELHKNAKEMQRHLK	acetylation	[1]
161	KEMQRHLKVVAEEFR	acetylation	[1]
181	NADALRAKFGLYSDQ	acetylation	[1]
201	AQRLTEIKNHPTLIE	acetylation	[1]
212	TLIEYHTKASDHLKT	acetylation	[1]
218	TKASDHLKTLGEKAK	acetylation	[1]
245	VLEAWKAKIMSMIDE	acetylation	[1]
254	MSMIDEAKKKLNA**	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. 

Sequence Annotation

 REPEAT 67 88 1.
 REPEAT 89 110 2.
 REPEAT 111 121 3; half-length.
 REPEAT 122 143 4.
 REPEAT 144 161 5; truncated.
 REPEAT 162 183 6.
 REPEAT 184 203 7; truncated.
 REPEAT 204 225 8.
 REPEAT 226 236 9; half-length.
 REPEAT 237 259 10.
 REGION 67 259 10 X approximate tandem repeats.
 MOD_RES 109 109 Methionine sulfoxide (By similarity).  

Keyword

 Cholesterol metabolism; Complete proteome; Direct protein sequencing; HDL; Lipid metabolism; Lipid transport; Lipoprotein; Oxidation; Palmitate; Phosphoprotein; Reference proteome; Repeat; Secreted; Signal; Steroid metabolism; Sterol metabolism; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 259 AA 

Protein Sequence

Gene Ontology

 GO:0030139; C:endocytic vesicle; IEA:Compara.
 GO:0005615; C:extracellular space; IDA:RGD.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0034366; C:spherical high-density lipoprotein particle; IEA:Compara.
 GO:0034361; C:very-low-density lipoprotein particle; IEA:Compara.
 GO:0001540; F:beta-amyloid binding; IEA:Compara.
 GO:0015485; F:cholesterol binding; IEA:Compara.
 GO:0017127; F:cholesterol transporter activity; IDA:RGD.
 GO:0008035; F:high-density lipoprotein particle binding; IEA:Compara.
 GO:0055102; F:lipase inhibitor activity; IDA:RGD.
 GO:0060228; F:phosphatidylcholine-sterol O-acyltransferase activator activity; IEA:Compara.
 GO:0005543; F:phospholipid binding; IEA:Compara.
 GO:0005548; F:phospholipid transporter activity; IDA:RGD.
 GO:0030325; P:adrenal gland development; IEA:Compara.
 GO:0043534; P:blood vessel endothelial cell migration; IEA:Compara.
 GO:0006695; P:cholesterol biosynthetic process; IEA:Compara.
 GO:0033344; P:cholesterol efflux; IEA:Compara.
 GO:0042632; P:cholesterol homeostasis; IEA:Compara.
 GO:0070508; P:cholesterol import; IEA:Compara.
 GO:0001935; P:endothelial cell proliferation; IEA:Compara.
 GO:0007186; P:G-protein coupled receptor signaling pathway; IEA:Compara.
 GO:0008211; P:glucocorticoid metabolic process; IEA:Compara.
 GO:0034380; P:high-density lipoprotein particle assembly; IEA:Compara.
 GO:0019915; P:lipid storage; IEA:Compara.
 GO:0042158; P:lipoprotein biosynthetic process; IEA:Compara.
 GO:0060354; P:negative regulation of cell adhesion molecule production; IEA:Compara.
 GO:0002740; P:negative regulation of cytokine secretion involved in immune response; IEA:Compara.
 GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IEA:Compara.
 GO:0050728; P:negative regulation of inflammatory response; IEA:Compara.
 GO:0050713; P:negative regulation of interleukin-1 beta secretion; IEA:Compara.
 GO:0060192; P:negative regulation of lipase activity; IDA:RGD.
 GO:0010804; P:negative regulation of tumor necrosis factor-mediated signaling pathway; IEA:Compara.
 GO:0010903; P:negative regulation of very-low-density lipoprotein particle remodeling; IEA:Compara.
 GO:0031100; P:organ regeneration; IDA:RGD.
 GO:0018206; P:peptidyl-methionine modification; IEA:Compara.
 GO:0014012; P:peripheral nervous system axon regeneration; IEP:RGD.
 GO:0006656; P:phosphatidylcholine biosynthetic process; IEA:Compara.
 GO:0033700; P:phospholipid efflux; IEA:Compara.
 GO:0055091; P:phospholipid homeostasis; IEA:Compara.
 GO:0010873; P:positive regulation of cholesterol esterification; IEA:Compara.
 GO:0051345; P:positive regulation of hydrolase activity; IEA:Compara.
 GO:0051347; P:positive regulation of transferase activity; IEA:Compara.
 GO:0018158; P:protein oxidation; IEA:Compara.
 GO:0050821; P:protein stabilization; IEA:Compara.
 GO:0032489; P:regulation of Cdc42 protein signal transduction; IEA:Compara.
 GO:0030300; P:regulation of intestinal cholesterol absorption; IEA:Compara.
 GO:0001932; P:regulation of protein phosphorylation; IEA:Compara.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0043627; P:response to estrogen stimulus; IEP:RGD.
 GO:0007584; P:response to nutrient; IEP:RGD.
 GO:0043691; P:reverse cholesterol transport; IEA:Compara.
 GO:0070328; P:triglyceride homeostasis; IEA:Compara. 

Interpro

 IPR013326; ApoA.
 IPR000074; ApoA1_A4_E. 

Pfam

 PF01442; Apolipoprotein 

SMART

  

PROSITE

  

PRINTS