UniProt Accession

 KHSE_YEAST; P17423; D3DKX2 

Genbank Protein ID

 X52901; M37692; U10399; BK006934 

Genbank Nucleotide ID

 CAA37083.1; AAA35154.1; AAB68871.1; DAA06716.1 

Protein Name

 Homoserine kinase 

Protein Synonyms/Alias

 HK; HSK 

Gene Name

 THR1 

Gene Synonyms/Alias

 YHR025W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
58	NCKLSYTKESEGYST	acetylation	[1]
58	NCKLSYTKESEGYST	ubiquitination	[2]
133	VAQLGFSKQRMLDYC	ubiquitination	[3]
207	TDIGRHVKYQWNPAI	ubiquitination	[2]
236	DSRGVLPKAYPTQDL	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [3] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047] 

Functional Description

 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity). 

Sequence Annotation

 NP_BIND 104 114 ATP (Potential).  

Keyword

 Amino-acid biosynthesis; ATP-binding; Complete proteome; Direct protein sequencing; Kinase; Nucleotide-binding; Reference proteome; Threonine biosynthesis; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 357 AA 

Protein Sequence

Gene Ontology

 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004413; F:homoserine kinase activity; IDA:SGD.
 GO:0009092; P:homoserine metabolic process; IDA:SGD.
 GO:0006549; P:isoleucine metabolic process; TAS:SGD.
 GO:0006555; P:methionine metabolic process; TAS:SGD.
 GO:0009088; P:threonine biosynthetic process; IMP:SGD. 

Interpro

 IPR006204; GHMP_kinase_N_dom.
 IPR006203; GHMP_knse_ATP-bd_CS.
 IPR000870; Homoserine_kinase.
 IPR020568; Ribosomal_S5_D2-typ_fold.
 IPR014721; Ribosomal_S5_D2-typ_fold_subgr. 

Pfam

 PF00288; GHMP_kinases_N 

SMART

  

PROSITE

 PS00627; GHMP_KINASES_ATP 

PRINTS

 PR00958; HOMSERKINASE.