UniProt Accession

 F213A_HUMAN; Q9BRX8; B2RD81; Q6UW08; Q8N2K3; Q8NBK9; Q96JR0 

Genbank Protein ID

 AY359059; AK315440; AK074643; AK075447; AC021028; BC005871; AF305824 

Genbank Nucleotide ID

 AAQ89418.1; BAG37828.1; BAC11108.1; BAC11627.1; AAH05871.3; AAK55527.1 

Protein Name

 Redox-regulatory protein FAM213A 

Protein Synonyms/Alias

 Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes; Protein PAMM 

Gene Name

 FAM213A 

Gene Synonyms/Alias

 C10orf58; PAMM; PRO2290; PSEC0139; UNQ611/PRO1198 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
122	EHIRTEVKDFQPYFK	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bone resorption and help to maintain bone mass. 

Sequence Annotation

 REGION 14 112 Thioredoxin fold (By similarity).
 ACT_SITE 85 85 Redox-active (By similarity).
 ACT_SITE 88 88 Redox-active (By similarity).  

Keyword

 Alternative splicing; Antioxidant; Complete proteome; Cytoplasm; Direct protein sequencing; Redox-active center; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 229 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0016209; F:antioxidant activity; IDA:UniProtKB.
 GO:0055114; P:oxidation-reduction process; IDA:UniProtKB.
 GO:0045670; P:regulation of osteoclast differentiation; IDA:UniProtKB. 

Interpro

 IPR012336; Thioredoxin-like_fold. 

Pfam

  

SMART

  

PROSITE

  

PRINTS