UniProt Accession

 HAOX2_MOUSE; Q9NYQ2; Q9JHS7; Q9JI00 

Genbank Protein ID

 AF231918; AF272947; AJ251820; AK078908 

Genbank Nucleotide ID

 AAF40201.1; AAF81795.1; CAB96380.1; BAC37452.1 

Protein Name

 Hydroxyacid oxidase 2 

Protein Synonyms/Alias

 HAOX2; (S)-2-hydroxy-acid oxidase, peroxisomal; Medium chain alpha-hydroxy acid oxidase; Medium-chain L-2-hydroxy acid oxidase 

Gene Name

 Hao2 

Gene Synonyms/Alias

 Hao3; Haox2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
224	TRLPIILKGILTKED	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Has 2-hydroxyacid oxidase activity. Most active on medium-chain substrates. 

Sequence Annotation

 DOMAIN 1 353 FMN hydroxy acid dehydrogenase.
 NP_BIND 279 303 FMN (By similarity).
 MOTIF 351 353 Microbody targeting signal (Potential).
 ACT_SITE 248 248 Proton acceptor (By similarity).
 BINDING 106 106 FMN (By similarity).
 BINDING 128 128 FMN (By similarity).
 BINDING 130 130 Substrate (By similarity).
 BINDING 156 156 FMN (By similarity).
 BINDING 165 165 Substrate (By similarity).
 BINDING 224 224 FMN (By similarity).
 BINDING 251 251 Substrate (Potential).
 BINDING 303 303 FMN (By similarity).  

Keyword

 Complete proteome; Flavoprotein; FMN; Oxidoreductase; Peroxisome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 353 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
 GO:0010181; F:FMN binding; IEA:Compara.
 GO:0052853; F:long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity; IEA:EC.
 GO:0052854; F:medium-chain-(S)-2-hydroxy-acid oxidase activity; IEA:EC.
 GO:0052852; F:very-long-chain-(S)-2-hydroxy-acid oxidase activity; IEA:EC.
 GO:0019395; P:fatty acid oxidation; IEA:Compara.
 GO:0018924; P:mandelate metabolic process; IEA:Compara.
 GO:0051260; P:protein homooligomerization; IEA:Compara. 

Interpro

 IPR013785; Aldolase_TIM.
 IPR012133; Alpha-hydoxy_acid_DH_FMN.
 IPR000262; FMN-dep_DH.
 IPR008259; FMN_hydac_DH_AS. 

Pfam

 PF01070; FMN_dh 

SMART

  

PROSITE

 PS00557; FMN_HYDROXY_ACID_DH_1
 PS51349; FMN_HYDROXY_ACID_DH_2 

PRINTS