UniProt Accession

 TONB_ECOLI; P02929; P76831; P94719; P94722; P94726; P94728; P94732; P94736; P94739; P97239 

Genbank Protein ID

 K00431; U24195; U24196; U24197; U24198; U24199; U24200; U24201; U24202; U24203; U24204; U24205; U24206; U00096; AP009048 

Genbank Nucleotide ID

 AAB59066.1; AAB60069.1; AAB60077.1; AAB60085.1; AAB60093.1; AAB60101.1; AAB60109.1; AAB60117.1; AAB60125.1; AAB60133.1; AAB60141.1; AAB60149.1; AAB60157.1; AAC74334.1; BAA14784.2 

Protein Name

 Protein TonB 

Protein Synonyms/Alias

  

Gene Name

 tonB 

Gene Synonyms/Alias

 exbA; b1252; JW5195 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
91	EAPVVIEKPKPKPKP	acetylation	[1]
93	PVVIEKPKPKPKPKP	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates such as cobalamin, and various iron compounds (such as iron dicitrate, enterochelin, aerobactin, etc.). In the absence of TonB these receptors bind their substrates but do not carry out active transport. TonB also interacts with some colicins and is involved in the energy- dependent, irreversible steps of bacteriophages phi 80 and T1 infection. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. 

Sequence Annotation

 REPEAT 70 71 1-1.
 REPEAT 72 73 1-2.
 REPEAT 74 75 1-3.
 REPEAT 76 77 1-4.
 REPEAT 78 79 1-5; approximate.
 REPEAT 80 81 1-6.
 REPEAT 91 92 2-1.
 REPEAT 93 94 2-2.
 REPEAT 95 96 2-3.
 REPEAT 97 98 2-4.
 REPEAT 99 100 2-5.
 REPEAT 101 102 2-6.
 REGION 70 81 6 X 2 AA approximate tandem repeats of E-
 REGION 91 102 6 X 2 AA tandem repeats of K-P.  

Keyword

 3D-structure; Bacteriocin transport; Cell inner membrane; Cell membrane; Complete proteome; Membrane; Protein transport; Reference proteome; Repeat; Signal-anchor; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 239 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031233; C:intrinsic to external side of plasma membrane; IMP:EcoCyc.
 GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.
 GO:0031992; F:energy transducer activity; IDA:EcoCyc.
 GO:0005381; F:iron ion transmembrane transporter activity; IEA:InterPro.
 GO:0008565; F:protein transporter activity; IEA:InterPro.
 GO:0015889; P:cobalamin transport; IMP:EcoCyc.
 GO:0042914; P:colicin transport; TAS:EcoCyc.
 GO:0015891; P:siderophore transport; TAS:EcoCyc. 

Interpro

 IPR003538; TonB.
 IPR006260; TonB_C. 

Pfam

 PF03544; TonB 

SMART

  

PROSITE

  

PRINTS

 PR01374; TONBPROTEIN.