CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033905
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Histone-arginine methyltransferase CARM1 
Protein Synonyms/Alias
  
Gene Name
 Carm1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
471SSNLLDLKNPFFRYTubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Methyltransferase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 651 AA 
Protein Sequence
MAAAAATAVG PGAGSAGVAG PGGAGPCATV SVFPGARLLT IGDANGEIQR HAEQQALRLE 60
VRAGPDAAGI ALYSHEDVCV FKCSVSRETE CSRVGRQSFI ITLGCNSVLI QFATPHDFCS 120
FYNILKTCRG HTLERSVFSE RTEESSAVQY FQFYGYLSQQ QNMMQDYVRT GTYQRAILQN 180
HTDFKDKIVL DVGCGSGILS FFAAQAGARK IYAVEASTMA QHAEVLVKSN NLTDRIVVIP 240
GKVEEVSLPE QVDIIISEPM GYMLFNERML ESYLHAKKYL KPSGNMFPTI GDVHLAPFTD 300
EQLYMEQFTK ANFWYQPSFH GVDLSALRGA AVDEYFRQPV VDTFDIRILM AKSVKYTVNF 360
LEAKEGDLHR IEIPFKFHML HSGLVHGLAF WFDVAFIGSI MTVWLSTAPT EPLTHWYQVR 420
CLFQSPLFAK AGDTLSGTCL LIANKRQSYD ISIVAQVDQT GSKSSNLLDL KNPFFRYTGT 480
TPSPPPGSHY TSPSENMWNT GSTYNLSSGV AVAGMPTAYD LSSVIAGGSS VGHNNLIPLA 540
NTGIVNHTHS RMGSIMSTGI VQGNRVVGPW AGDVPPGLRT RSSYQWGPGR LRGHAGSSVP 600
VTCPTGSSGA QGGGGSSSAH YAVNNQFTMG GPAISMASPM SIPTNTMHYG S 651 
Gene Ontology
 GO:0008276; F:protein methyltransferase activity; IDA:MGI.
 GO:0003713; F:transcription coactivator activity; IDA:MGI.
 GO:0060350; P:endochondral bone morphogenesis; IMP:MGI.
 GO:0016571; P:histone methylation; IDA:MGI.
 GO:0030520; P:intracellular estrogen receptor signaling pathway; IGI:MGI.
 GO:0032091; P:negative regulation of protein binding; IDA:MGI.
 GO:0009405; P:pathogenesis; IEA:InterPro.
 GO:0008284; P:positive regulation of cell proliferation; IMP:MGI.
 GO:0003420; P:regulation of growth plate cartilage chondrocyte proliferation; IMP:MGI.
 GO:0006355; P:regulation of transcription, DNA-dependent; IDA:MGI. 
Interpro
 IPR025799; Arg_MeTrfase.
 IPR025797; Arg_MeTrfase_CARM1.
 IPR020989; Histone-Arg_MeTrfase_N. 
Pfam
 PF11531; CARM1
 PF05185; PRMT5 
SMART
  
PROSITE
 PS51628; SAM_PRMT_1 
PRINTS