CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020016
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 B-cell lymphoma/leukemia 11B 
Protein Synonyms/Alias
 BCL-11B; B-cell CLL/lymphoma 11B; COUP-TF-interacting protein 2; Radiation-induced tumor suppressor gene 1 protein; mRit1 
Gene Name
 Bcl11b 
Gene Synonyms/Alias
 Ctip2; Rit1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
679LHAAKRIKVEKDLELsumoylation[1]
877HLLTNDVKIEQAERSsumoylation[1]
Reference
 [1] Coordinated regulation of transcription factor Bcl11b activity in thymocytes by the mitogen-activated protein kinase (MAPK) pathways and protein sumoylation.
 Zhang LJ, Vogel WK, Liu X, Topark-Ngarm A, Arbogast BL, Maier CS, Filtz TM, Leid M.
 J Biol Chem. 2012 Aug 3;287(32):26971-88. [PMID: 22700985] 
Functional Description
 Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element. 
Sequence Annotation
 ZN_FING 221 251 C2H2-type 1.
 ZN_FING 426 453 C2H2-type 2.
 ZN_FING 454 481 C2H2-type 3.
 ZN_FING 786 813 C2H2-type 4.
 ZN_FING 814 843 C2H2-type 5.
 ZN_FING 844 874 C2H2-type 6.
 MOD_RES 96 96 Phosphoserine (By similarity).
 MOD_RES 119 119 Phosphothreonine (By similarity).
 MOD_RES 256 256 Phosphoserine (By similarity).
 MOD_RES 260 260 Phosphothreonine (By similarity).
 MOD_RES 277 277 Phosphoserine (By similarity).
 MOD_RES 358 358 Phosphoserine (By similarity).
 MOD_RES 376 376 Phosphothreonine (By similarity).
 MOD_RES 381 381 Phosphoserine (By similarity).
 MOD_RES 398 398 Phosphoserine (By similarity).
 MOD_RES 416 416 Phosphothreonine (By similarity).
 MOD_RES 482 482 Phosphoserine (By similarity).
 MOD_RES 487 487 Phosphoserine (By similarity).
 MOD_RES 495 495 Phosphoserine (By similarity).
 MOD_RES 496 496 Phosphoserine (By similarity).
 MOD_RES 664 664 Phosphoserine (By similarity).
 MOD_RES 755 755 Phosphoserine (By similarity).
 MOD_RES 841 841 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 884 AA 
Protein Sequence
MSRRKQGNPQ HLSQRELITP EADHVEATIL EEDEGLEIEE PSSLGLMVGG PDPDLLTCGQ 60
CQMNFPLGDI LVFIEHKKKQ CGGLGPCYDK VLDKSSPPPS SRSELRRVSE PVEIGIQVTP 120
DEDDHLLSPT KGICPKQENI AGPCRPAQLP SMAPIAASSS HPPTSVITSP LRALGVLPPC 180
FPLPCCGARP ISGDGTQGEG QMEAPFGCQC ELSGKDEPSS YICTTCKQPF NSAWFLLQHA 240
QNTHGFRIYL EPGPASTSLT PRLTIPPPLG PETVAQSPLM NFLGDSNPFN LLRMTGPILR 300
DHPGFGEGRL PGTPPLFSPP PRHHLDPHRL SAEEMGLVAQ HPSAFDRVMR LNPMAIDSPA 360
MDFSRRLREL AGNSSTPPPV SPGRGNPMHR LLNPFQPSPK SPFLSTPPLP PMPAGTPPPQ 420
PPAKSKSCEF CGKTFKFQSN LIVHRRSHTG EKPYKCQLCD HACSQASKLK RHMKTHMHKA 480
GSLAGRSDDG LSAASSPEPG TSELPGDLKA ADGDFRHHES DPSLGPEPED DEDEEEEEEE 540
LLLENESRPE SSFSMDSELG RGRENGGGVP PGVAGAGAAA AALADEKALA LGKVMEDAGL 600
GALPQYGEKR GAFLKRAGDT GDAGAVGCGD AGAPGAVNGR GGAFAPGAEP FPALFPRKPA 660
PLPSPGLGGP ALHAAKRIKV EKDLELPPAA LIPSENVYSQ WLVGYAASRH FMKDPFLGFT 720
DARQSPFATS SEHSSENGSL RFSTPPGDLL DGGLSGRSGT ASGGSTPHLG GPGPGRPSSK 780
EGRRSDTCEY CGKVFKNCSN LTVHRRSHTG ERPYKCELCN YACAQSSKLT RHMKTHGQIG 840
KEVYRCDICQ MPFSVYSTLE KHMKKWHGEH LLTNDVKIEQ AERS 884 
Gene Ontology
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IDA:MGI.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0046632; P:alpha-beta T cell differentiation; IMP:MGI.
 GO:0003382; P:epithelial cell morphogenesis; IMP:MGI.
 GO:0003334; P:keratinocyte development; IMP:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.
 GO:0008285; P:negative regulation of cell proliferation; IDA:MGI.
 GO:0042475; P:odontogenesis of dentin-containing tooth; IMP:MGI.
 GO:0071678; P:olfactory bulb axon guidance; IMP:MGI.
 GO:0043368; P:positive T cell selection; IMP:MGI.
 GO:0031077; P:post-embryonic camera-type eye development; IMP:MGI.
 GO:0010837; P:regulation of keratinocyte proliferation; IMP:MGI.
 GO:0019216; P:regulation of lipid metabolic process; IMP:MGI.
 GO:0045664; P:regulation of neuron differentiation; IMP:MGI.
 GO:0043588; P:skin development; IMP:MGI.
 GO:0021773; P:striatal medium spiny neuron differentiation; IMP:MGI.
 GO:0033077; P:T cell differentiation in thymus; IMP:MGI.
 GO:0033153; P:T cell receptor V(D)J recombination; IMP:MGI.
 GO:0048538; P:thymus development; IMP:MGI. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF00096; zf-C2H2 
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS