UniProt Accession

 RAB3B_HUMAN; P20337; Q5VUL2; Q9BSI1 

Genbank Protein ID

 M28214; AF498932; AL589663; AL445685; AL445685; AL589663; BC005035 

Genbank Nucleotide ID

 AAA60243.1; AAM21080.1; CAH74098.1; CAH74098.1; CAI17027.1; CAI17027.1; AAH05035.1 

Protein Name

 Ras-related protein Rab-3B 

Protein Synonyms/Alias

  

Gene Name

 RAB3B 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
12	TDGKTGVKDASDQNF	ubiquitination	[1]
72	YRHEKRVKLQIWDTA	ubiquitination	[2]
149	ERVVPTEKGQLLAEQ	ubiquitination	[1, 3]
202	PSMLGSSKNTRLSDT	ubiquitination	[1, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Protein transport. Probably involved in vesicular traffic (By similarity). 

Sequence Annotation

 NP_BIND 29 37 GTP.
 NP_BIND 48 54 GTP (By similarity).
 NP_BIND 77 81 GTP (By similarity).
 NP_BIND 135 138 GTP.
 NP_BIND 165 167 GTP.
 MOTIF 51 59 Effector region (By similarity).
 MOD_RES 188 188 Phosphoserine (By similarity).
 MOD_RES 190 190 Phosphoserine.
 MOD_RES 219 219 Cysteine methyl ester (By similarity).
 LIPID 217 217 S-geranylgeranyl cysteine (By
 LIPID 219 219 S-geranylgeranyl cysteine (By  

Keyword

 3D-structure; Cell membrane; Complete proteome; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Phosphoprotein; Prenylation; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 219 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0030141; C:secretory granule; IEA:Compara.
 GO:0008021; C:synaptic vesicle; IEA:Compara.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; TAS:ProtInc.
 GO:0018125; P:peptidyl-cysteine methylation; IEA:Compara.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0017157; P:regulation of exocytosis; IEA:Compara.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 

Pfam

 PF00071; Ras 

SMART

 SM00175; RAB 

PROSITE

 PS51419; RAB 

PRINTS

 PR00449; RASTRNSFRMNG.