UniProt Accession

 TXN4A_HUMAN; P83876; B2RC18; O14834 

Genbank Protein ID

 AF023611; AF146373; AK314901; CH471117; BC001046; BC019272 

Genbank Nucleotide ID

 AAB81950.1; AAF17332.1; BAG37415.1; EAW66640.1; AAH01046.1; AAH19272.1 

Protein Name

 Thioredoxin-like protein 4A 

Protein Synonyms/Alias

 DIM1 protein homolog; Spliceosomal U5 snRNP-specific 15 kDa protein; Thioredoxin-like U5 snRNP protein U5-15kD 

Gene Name

 TXNL4A 

Gene Synonyms/Alias

 DIM1; TXNL4 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
51	VLYSIAEKVKNFAVI	ubiquitination	[1, 2]
134	RGLVVSPKDYSTKYR	ubiquitination	[1, 2, 3]
139	SPKDYSTKYRY****	ubiquitination	[1, 2, 3, 4, 5]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly. 

Sequence Annotation

 MOD_RES 132 132 Phosphoserine.
 DISULFID 38 79  

Keyword

 3D-structure; Cell cycle; Cell division; Complete proteome; Direct protein sequencing; Disulfide bond; Mitosis; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 142 AA 

Protein Sequence

Gene Ontology

 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0005681; C:spliceosomal complex; TAS:UniProtKB.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007067; P:mitosis; NAS:UniProtKB.
 GO:0000245; P:spliceosomal complex assembly; TAS:UniProtKB. 

Interpro

 IPR004123; mRNA_splic_U5.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF02966; DIM1 

SMART

  

PROSITE

  

PRINTS