CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013890
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 60 kDa chaperonin 
Protein Synonyms/Alias
 GroEL protein; Heat shock protein 60; Protein Cpn60 
Gene Name
 groL 
Gene Synonyms/Alias
 cpnL; groEL; hsp60; mopA; TTHA0271 
Created Date
 July 27, 2013 
Organism
 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) 
NCBI Taxa ID
 300852 
Lysine Modification
Position
Peptide
Type
References
74NIGAQLLKEVASKTNacetylation[1]
129AVEAAVEKIKALAIPacetylation[1]
166LIADAMEKVGKEGIIacetylation[1]
169DAMEKVGKEGIITVEacetylation[1]
336TIVGGKGKKEDIEARacetylation[1]
337IVGGKGKKEDIEARIacetylation[1]
349ARINGIKKELETTDSacetylation[1]
388AATETELKEKKHRFEacetylation[1]
390TETELKEKKHRFEDAacetylation[1]
429SAVEELIKKLEGDEAacetylation[1]
430AVEELIKKLEGDEATacetylation[1]
440GDEATGAKIVRRALEacetylation[1]
Reference
 [1] Acetylome with structural mapping reveals the significance of lysine acetylation in Thermus thermophilus.
 Okanishi H, Kim K, Masui R, Kuramitsu S.
 J Proteome Res. 2013 Aug 1;. [PMID: 23901841] 
Functional Description
 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. 
Sequence Annotation
  
Keyword
 ATP-binding; Chaperone; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 543 AA 
Protein Sequence
MAKILVFDEA ARRALERGVN AVANAVKVTL GPRGRNVVLE KKFGSPTITK DGVTVAKEVE 60
LEDHLENIGA QLLKEVASKT NDVAGDGTTT ATVLAQAIVR EGLKNVAAGA NPLALKRGIE 120
KAVEAAVEKI KALAIPVEDR KAIEEVATIS ANDPEVGKLI ADAMEKVGKE GIITVEESKS 180
LETELKFVEG YQFDKGYISP YFVTNPETME AVLEDAFILI VEKKVSNVRE LLPILEQVAQ 240
TGKPLLIIAE DVEGEALATL VVNKLRGTLS VAAVKAPGFG DRRKEMLKDI AAVTGGTVIS 300
EELGFKLENA TLSMLGRAER VRITKDETTI VGGKGKKEDI EARINGIKKE LETTDSEYAR 360
EKLQERLAKL AGGVAVIRVG AATETELKEK KHRFEDALNA TRAAVEEGIV PGGGVTLLRA 420
ISAVEELIKK LEGDEATGAK IVRRALEEPA RQIAENAGYE GSVIVQQILA ETKNPRYGFN 480
AATGEFVDMV EAGIVDPAKV TRSALQNAAS IGALILTTEA VVAEKPEKKE STPASAGAGD 540
MDF 543 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0042026; P:protein refolding; IEA:HAMAP. 
Interpro
 IPR018370; Chaperonin_Cpn60_CS.
 IPR001844; Chaprnin_Cpn60.
 IPR002423; Cpn60/TCP-1.
 IPR027409; GroEL-like_apical_dom.
 IPR027413; GROEL-like_equatorial. 
Pfam
 PF00118; Cpn60_TCP1 
SMART
  
PROSITE
 PS00296; CHAPERONINS_CPN60 
PRINTS
 PR00298; CHAPERONIN60.