UniProt Accession

 DPYL2_RAT; P47942 

Genbank Protein ID

 Z46882 

Genbank Nucleotide ID

 CAA86981.1 

Protein Name

 Dihydropyrimidinase-related protein 2 

Protein Synonyms/Alias

 DRP-2; Collapsin response mediator protein 2; CRMP-2; Turned on after division 64 kDa protein; TOAD-64 

Gene Name

 Dpysl2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
6	**MSYQGKKNIPRIT	acetylation	[1]
56	LIVPGGVKTIEAHSR	acetylation	[1]
56	LIVPGGVKTIEAHSR	ubiquitination	[2]
345	TAQKAVGKDNFTLIP	acetylation	[1]
345	TAQKAVGKDNFTLIP	ubiquitination	[2]
368	RMSVIWDKAVVTGKM	ubiquitination	[2]
374	DKAVVTGKMDENQFV	acetylation	[1]
418	IWDPDSVKTISAKTH	acetylation	[1]
472	SGRYIPRKPFPDFVY	acetylation	[1]
472	SGRYIPRKPFPDFVY	ubiquitination	[2]
480	PFPDFVYKRIKARSR	acetylation	[1]
520	VTPASSAKTSPAKQQ	ubiquitination	[2]
525	SAKTSPAKQQAPPVR	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Plays a role in neuronal development and polarity, as well as in neuron projection morphogenesis, axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). 

Sequence Annotation

 MOD_RES 32 32 Phosphotyrosine; by FYN (By similarity).
 MOD_RES 431 431 Phosphotyrosine (By similarity).
 MOD_RES 462 462 Phosphothreonine (By similarity).
 MOD_RES 465 465 Phosphoserine (By similarity).
 MOD_RES 499 499 Phosphotyrosine (By similarity).
 MOD_RES 509 509 Phosphothreonine.
 MOD_RES 514 514 Phosphothreonine; by GSK3-beta (By
 MOD_RES 517 517 Phosphoserine (By similarity).
 MOD_RES 518 518 Phosphoserine.
 MOD_RES 522 522 Phosphoserine; alternate.
 MOD_RES 522 522 Phosphoserine; by DYRK2; alternate (By
 MOD_RES 542 542 Phosphoserine (By similarity).
 MOD_RES 555 555 Phosphothreonine; by ROCK2 (By  

Keyword

 Complete proteome; Cytoplasm; Developmental protein; Differentiation; Direct protein sequencing; Neurogenesis; Phosphoprotein; Reference proteome; S-nitrosylation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 572 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; IEA:Compara.
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0030425; C:dendrite; IDA:RGD.
 GO:0030426; C:growth cone; IDA:RGD.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0043025; C:neuronal cell body; IDA:RGD.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0016812; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides; IEA:InterPro.
 GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.
 GO:0021772; P:olfactory bulb development; IEP:RGD.
 GO:0014049; P:positive regulation of glutamate secretion; IDA:RGD.
 GO:0006208; P:pyrimidine nucleobase catabolic process; IEA:InterPro.
 GO:0030516; P:regulation of axon extension; NAS:RGD.
 GO:0001975; P:response to amphetamine; IEP:RGD.
 GO:0042220; P:response to cocaine; IEP:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0021510; P:spinal cord development; IEP:RGD.
 GO:0048489; P:synaptic vesicle transport; IDA:RGD. 

Interpro

 IPR006680; Amidohydro_1.
 IPR011778; Hydantoinase/dihydroPyrase.
 IPR011059; Metal-dep_hydrolase_composite. 

Pfam

 PF01979; Amidohydro_1 

SMART

  

PROSITE

  

PRINTS