CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022077
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Striatin-4 
Protein Synonyms/Alias
 Zinedin 
Gene Name
 STRN4 
Gene Synonyms/Alias
 ZIN 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
136RAKYHKLKFGTDLNQacetylation[1]
431FKKTWNPKFTLRSHYubiquitination[2]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein. 
Sequence Annotation
 REPEAT 436 475 WD 1.
 REPEAT 489 528 WD 2.
 REPEAT 542 581 WD 3.
 REPEAT 587 628 WD 4.
 REPEAT 635 674 WD 5.
 REPEAT 677 716 WD 6.
 REPEAT 723 752 WD 7.
 REGION 71 79 Caveolin-binding (Potential).
 REGION 165 182 Calmodulin-binding (Potential).
 MOD_RES 53 53 Phosphoserine.
 MOD_RES 206 206 Phosphoserine.
 MOD_RES 276 276 Phosphoserine.  
Keyword
 Calmodulin-binding; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 753 AA 
Protein Sequence
MMEERAAAAV AAAASSCRPL GSGAGPGPTG AAPVSAPAPG PGPAGKGGGG GGSPGPTAGP 60
EPLSLPGILH FIQHEWARFE AEKARWEAER AELQAQVAFL QGERKGQENL KTDLVRRIKM 120
LEYALKQERA KYHKLKFGTD LNQGEKKADV SEQVSNGPVE SVTLENSPLV WKEGRQLLRQ 180
YLEEVGYTDT ILDMRSKRVR SLLGRSLELN GAVEPSEGAP RAPPGPAGLS GGESLLVKQI 240
EEQIKRNAAG KDGKERLGGS VLGQIPFLQN CEDEDSDEDD ELDSVQHKKQ RVKLPSKALV 300
PEMEDEDEED DSEDAINEFD FLGSGEDGEG APDPRRCTVD GSPHELESRR VKLQGILADL 360
RDVDGLPPKV TGPPPGTPQP RPHEDVFIMD TIGGGEVSLG DLADLTVTND NDLSCDLSDS 420
KDAFKKTWNP KFTLRSHYDG IRSLAFHHSQ SALLTASEDG TLKLWNLQKA VTAKKNAALD 480
VEPIHAFRAH RGPVLAVAMG SNSEYCYSGG ADACIHSWKI PDLSMDPYDG YDPSVLSHVL 540
EGHGDAVWGL AFSPTSQRLA SCSADGTVRI WDPSSSSPAC LCTFPTASEH GVPTSVAFTS 600
TEPAHIVASF RSGDTVLYDM EVGSALLTLE SRGSSGPTQI NQVVSHPNQP LTITAHDDRG 660
IRFLDNRTGK PVHSMVAHLD AVTCLAVDPN GAFLMSGSHD CSLRLWSLDN KTCVQEITAH 720
RKKHEEAIHA VACHPSKALI ASAGADALAK VFV 753 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0005516; F:calmodulin binding; NAS:UniProtKB.
 GO:0032403; F:protein complex binding; IDA:UniProtKB.
 GO:0051721; F:protein phosphatase 2A binding; IDA:UniProtKB. 
Interpro
 IPR020472; G-protein_beta_WD-40_rep.
 IPR013258; Striatin_N.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF08232; Striatin
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00320; GPROTEINBRPT.