UniProt Accession

 H7BYM0_HUMAN; H7BYM0 

Genbank Protein ID

 AC027228 

Genbank Nucleotide ID

  

Protein Name

 Neuronal acetylcholine receptor subunit alpha-5 

Protein Synonyms/Alias

  

Gene Name

 CHRNA5 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
88	RFEGTSTKTVIRYNG	ubiquitination	[1, 2, 3]
166	IVSATGSKGNRTDSC	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

  

Sequence Annotation

  

Keyword

 Cell junction; Cell membrane; Complete proteome; Ion channel; Ion transport; Ligand-gated ion channel; Membrane; Postsynaptic cell membrane; Receptor; Reference proteome; Synapse; Transmembrane; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 182 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
 GO:0004889; F:acetylcholine-activated cation-selective channel activity; IEA:InterPro. 

Interpro

 IPR006202; Neur_chan_lig-bd.
 IPR006201; Neur_channel.
 IPR018000; Neurotransmitter_ion_chnl_CS.
 IPR002394; Nicotinic_acetylcholine_rcpt. 

Pfam

 PF02931; Neur_chan_LBD 

SMART

  

PROSITE

 PS00236; NEUROTR_ION_CHANNEL 

PRINTS

 PR00254; NICOTINICR.
 PR00252; NRIONCHANNEL.