CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021914
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Histone H2B.7 
Protein Synonyms/Alias
 HTB11 
Gene Name
 At3g46030; F16L2.240 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Arabidopsis thaliana (Mouse-ear cress) 
NCBI Taxa ID
 3702 
Lysine Modification
Position
Peptide
Type
References
4****MAPKAEKKPAEmethylation[1]
7*MAPKAEKKPAEKKPacetylation[2]
12AEKKPAEKKPVEEKSacetylation[2]
23EEKSKAEKAPAEKKPacetylation[2]
28AEKAPAEKKPKAGKKacetylation[2]
29EKAPAEKKPKAGKKLacetylation[3]
34EKKPKAGKKLPKEAGacetylation[2]
35KKPKAGKKLPKEAGAacetylation[2]
Reference
 [1] Update on activities at the Universal Protein Resource (UniProt) in 2013.
 e="String">UniProt Consortium.
 Nucleic Acids Res. 2013 Jan;41(Database issue):D43-7. [PMID: 23161681]
 [2] Characterization of post-translational modifications of histone H2B-variants isolated from Arabidopsis thaliana.
 Bergmüller E, Gehrig PM, Gruissem W.
 J Proteome Res. 2007 Sep;6(9):3655-68. [PMID: 17691833]
 [3] Proteins of diverse function and subcellular location are lysine acetylated in Arabidopsis.
 Finkemeier I, Laxa M, Miguet L, Howden AJ, Sweetlove LJ.
 Plant Physiol. 2011 Apr;155(4):1779-90. [PMID: 21311031
Functional Description
 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. 
Sequence Annotation
 MOD_RES 2 2 N,N,N-trimethylalanine; alternate.
 MOD_RES 2 2 N,N-dimethylalanine; alternate.
 MOD_RES 2 2 N-methylalanine; alternate.
 MOD_RES 4 4 N6-methyllysine; partial.
 MOD_RES 7 7 N6-acetyllysine.
 MOD_RES 12 12 N6-acetyllysine.
 MOD_RES 23 23 N6-acetyllysine.
 MOD_RES 28 28 N6-acetyllysine.
 MOD_RES 34 34 N6-acetyllysine.
 MOD_RES 35 35 N6-acetyllysine; partial.
 CROSSLNK 141 141 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Acetylation; Chromosome; Complete proteome; DNA-binding; Isopeptide bond; Methylation; Nucleosome core; Nucleus; Reference proteome; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 145 AA 
Protein Sequence
MAPKAEKKPA EKKPVEEKSK AEKAPAEKKP KAGKKLPKEA GAGGDKKKKM KKKSVETYKI 60
YIFKVLKQVH PDIGISSKAM GIMNSFINDI FEKLASESSK LARYNKKPTI TSREIQTAVR 120
LVLPGELAKH AVSEGTKAVT KFTSS 145 
Gene Ontology
 GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0009506; C:plasmodesma; IDA:TAIR.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006334; P:nucleosome assembly; IEA:InterPro. 
Interpro
 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR000558; Histone_H2B. 
Pfam
 PF00125; Histone 
SMART
 SM00427; H2B 
PROSITE
 PS00357; HISTONE_H2B 
PRINTS
 PR00621; HISTONEH2B.