UniProt Accession

 IF5A2_YEAST; P19211; D6VWL8 

Genbank Protein ID

 J05455; M63542; M60477; L36344; Z49547; AY557894; X56235; BK006943 

Genbank Nucleotide ID

 AAA34425.1; AAA35156.1; AAA34424.1; AAA88750.1; CAA89575.1; AAS56220.1; CAA39692.1; DAA08834.1 

Protein Name

 Eukaryotic translation initiation factor 5A-2 

Protein Synonyms/Alias

 eIF-5A-2; Anaerobically induced protein 1; Hypusine-containing protein HP1; eIF-4D 

Gene Name

 ANB1 

Gene Synonyms/Alias

 HYP1; TIF51B; YJR047C; J1651 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
28	MQCSALRKNGFVVIK	acetylation	[1]
28	MQCSALRKNGFVVIK	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Essential for polarized growth, a process necessary for G1/S transition. May mediate large range of effects of the polyamine spermidine in the cell (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 2 2 Phosphoserine.
 MOD_RES 7 7 Phosphothreonine.
 MOD_RES 51 51 Hypusine.
 MOD_RES 74 74 Phosphoserine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Elongation factor; Hypusine; Phosphoprotein; Protein biosynthesis; Reference proteome; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 157 AA 

Protein Sequence

Gene Ontology

 GO:0022626; C:cytosolic ribosome; ISA:SGD.
 GO:0043022; F:ribosome binding; ISA:SGD.
 GO:0003746; F:translation elongation factor activity; ISA:SGD.
 GO:0008612; P:peptidyl-lysine modification to hypusine; IEA:InterPro.
 GO:0045901; P:positive regulation of translational elongation; ISA:SGD.
 GO:0045905; P:positive regulation of translational termination; ISA:SGD.
 GO:0006452; P:translational frameshifting; ISA:SGD. 

Interpro

 IPR005824; KOW.
 IPR012340; NA-bd_OB-fold.
 IPR014722; Rib_L2_dom2.
 IPR019769; Trans_elong_IF5A_hypusine_site.
 IPR001884; Transl_elong_IF5A.
 IPR020189; Transl_elong_IF5A_C.
 IPR008991; Translation_prot_SH3-like. 

Pfam

 PF01287; eIF-5a
 PF00467; KOW 

SMART

  

PROSITE

 PS00302; IF5A_HYPUSINE 

PRINTS