UniProt Accession

 IRK10_HUMAN; P78508; A3KME7; Q5VUT9; Q8N4I7; Q92808 

Genbank Protein ID

 U73192; U73193; U52155; AL513302; CH471121; BC034036; BC131627 

Genbank Nucleotide ID

 AAC50923.1; AAC50924.1; AAB07046.1; CAH71493.1; EAW52749.1; AAH34036.2; AAI31628.1 

Protein Name

 ATP-sensitive inward rectifier potassium channel 10 

Protein Synonyms/Alias

 ATP-dependent inwardly rectifying potassium channel Kir4.1; Inward rectifier K(+) channel Kir1.2; Potassium channel, inwardly rectifying subfamily J member 10 

Gene Name

 KCNJ10 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
224	LLQTHQTKEGENIRL	ubiquitination	[1]
335	SLFDQVVKVASPSGL	ubiquitination	[1]
354	VRYGDPEKLKLEESL	ubiquitination	[1]
356	YGDPEKLKLEESLRE	ubiquitination	[1]
367	SLREQAEKEGSALSV	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). 

Sequence Annotation

 NP_BIND 210 217 ATP (Potential).
 MOTIF 128 133 Selectivity filter (By similarity).  

Keyword

 ATP-binding; Complete proteome; Deafness; Disease mutation; Epilepsy; Ion channel; Ion transport; Membrane; Mental retardation; Nucleotide-binding; Polymorphism; Potassium; Potassium transport; Reference proteome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 379 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0016323; C:basolateral plasma membrane; IEA:Compara.
 GO:0016010; C:dystrophin-associated glycoprotein complex; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005902; C:microvillus; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0015272; F:ATP-activated inward rectifier potassium channel activity; TAS:ProtInc.
 GO:0007628; P:adult walking behavior; IEA:Compara.
 GO:0022010; P:central nervous system myelination; IEA:Compara.
 GO:0006954; P:inflammatory response; IEA:Compara.
 GO:0051935; P:L-glutamate uptake involved in synaptic transmission; IEA:Compara.
 GO:0060081; P:membrane hyperpolarization; IEA:Compara.
 GO:0021554; P:optic nerve development; IEA:Compara.
 GO:0055075; P:potassium ion homeostasis; IEA:Compara.
 GO:0010107; P:potassium ion import; IEA:Compara.
 GO:0051289; P:protein homotetramerization; IEA:Compara.
 GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Compara.
 GO:0060075; P:regulation of resting membrane potential; IEA:Compara.
 GO:0051930; P:regulation of sensory perception of pain; IEA:Compara.
 GO:0009637; P:response to blue light; IEA:Compara.
 GO:0051384; P:response to glucocorticoid stimulus; IEA:Compara.
 GO:0051385; P:response to mineralocorticoid stimulus; IEA:Compara.
 GO:0007268; P:synaptic transmission; TAS:Reactome.
 GO:0007601; P:visual perception; IEA:Compara. 

Interpro

 IPR014756; Ig_E-set.
 IPR016449; K_chnl_inward-rec_Kir.
 IPR003269; K_chnl_inward-rec_Kir1.2.
 IPR013518; K_chnl_inward-rec_Kir_cyto. 

Pfam

 PF01007; IRK 

SMART

  

PROSITE

  

PRINTS

 PR01322; KIR12CHANNEL.
 PR01320; KIRCHANNEL.