UniProt Accession

 CBWD3_HUMAN; Q5JTY5 

Genbank Protein ID

 AL353608 

Genbank Nucleotide ID

 CAI41162.1 

Protein Name

 COBW domain-containing protein 3 

Protein Synonyms/Alias

 Cobalamin synthase W domain-containing protein 3 

Gene Name

 CBWD3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
69	ILTEQHSKRVAVILN	ubiquitination	[1, 2, 3]
113	GCLCCSVKDNGLRAI	ubiquitination	[2]
370	NLDKDILKQLFIATV	ubiquitination	[1, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

  

Sequence Annotation

 DOMAIN 274 377 CobW C-terminal.
 NP_BIND 49 56 ATP (Potential).
 NP_BIND 110 114 ATP (Potential).
 NP_BIND 203 206 ATP (Potential).  

Keyword

 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 395 AA 

Protein Sequence

Gene Ontology

 GO:0005524; F:ATP binding; IEA:UniProtKB-KW. 

Interpro

 IPR011629; Cbl_biosynth_CobW-like_C.
 IPR003495; CobW/HypB/UreG_dom.
 IPR027417; P-loop_NTPase. 

Pfam

 PF02492; cobW
 PF07683; CobW_C 

SMART

 SM00833; CobW_C 

PROSITE

  

PRINTS