UniProt Accession

 ZNT7_HUMAN; Q8NEW0; B2R949; D3DT61; Q8TCH2 

Genbank Protein ID

 AF529197; AY094606; AF233345; AK313638; BX537375; AL732465; AC104506; CH471097; CH471097; BC064692 

Genbank Nucleotide ID

 AAO17324.1; AAM21969.1; AAL83716.1; BAG36396.1; CAD97617.1; CAI13301.1; CAI13301.1; EAW72942.1; EAW72943.1; AAH64692.1 

Protein Name

 Zinc transporter 7 

Protein Synonyms/Alias

 ZnT-7; Solute carrier family 30 member 7; Znt-like transporter 2 

Gene Name

 SLC30A7 

Gene Synonyms/Alias

 ZNT7; ZNTL2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
15	DDEYKPPKFNLFGKI	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc- requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP (By similarity). 

Sequence Annotation

 REGION 161 218 His-rich loop.  

Keyword

 Complete proteome; Golgi apparatus; Ion transport; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 376 AA 

Protein Sequence

Gene Ontology

 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:Compara.
 GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0031982; C:vesicle; IDA:BHF-UCL.
 GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0032119; P:sequestering of zinc ion; IEA:Compara.
 GO:0055085; P:transmembrane transport; TAS:Reactome.
 GO:0006829; P:zinc ion transport; IEA:UniProtKB-KW. 

Interpro

 IPR002524; Cation_efflux.
 IPR027469; Cation_efflux_TMD. 

Pfam

 PF01545; Cation_efflux 

SMART

  

PROSITE

  

PRINTS