CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000956
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ran-binding protein 6 
Protein Synonyms/Alias
 RanBP6 
Gene Name
 RANBP6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
16VPATVSEKQEFYQLLubiquitination[1, 2, 3, 4]
445FAPNFQKKFHETVIAubiquitination[3]
621SAWARMCKILGKDFQubiquitination[3]
625RMCKILGKDFQQYLPubiquitination[3]
986NCISAIGKILKFKPNubiquitination[3]
1067NYEDPCAKRLANVVRubiquitination[3, 5]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 May function in nuclear protein import as nuclear transport receptor. 
Sequence Annotation
 REPEAT 219 257 HEAT 1.
 REPEAT 361 399 HEAT 2.
 REPEAT 402 440 HEAT 3.
 REPEAT 444 483 HEAT 4.
 REPEAT 866 905 HEAT 5.
 REPEAT 908 946 HEAT 6.
 REPEAT 949 987 HEAT 7.
 REGION 333 383 Ran-GTP binding (By similarity).
 MOD_RES 2 2 N-acetylalanine.  
Keyword
 Acetylation; Coiled coil; Complete proteome; Cytoplasm; Nucleus; Protein transport; Reference proteome; Repeat; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1105 AA 
Protein Sequence
MAATASAGVP ATVSEKQEFY QLLKNLINPS CMVRRQAEEI YENIPGLCKT TFLLDAVRNR 60
RAGYEVRQMA AALLRRLLSS GFEEVYPNLP ADVQRDVKIE LILAVKLETH ASMRKKLCDI 120
FAVLARNLID EDGTNHWPEG LKFLIDSIYS KNVVLWEVAL HVFWHFPGIF GTQERHDLDI 180
IKRLLDQCIQ DQEHPAIRTL SARAAAAFVL ANENNIALFK DFADLLPGIL QAVNDSCYQD 240
DDSVLESLVE IADTVPKYLG PYLEDTLQLS LKLCGDSRLS NLQRQLALEV IVTLSETATP 300
MLKKHTNIIA QAVPHILAMM VDLQDDEDWV NADEMEEDDF DSNAVAAESA LDRLACGLGG 360
KVVLPMTKEH IMQMLQSPDW KYRHAGLMAL SAIGEGCHQQ MESILDETVN SVLLFLQDPH 420
PRVRAAACTT LGQMATDFAP NFQKKFHETV IAALLRTMEN QGNQRVQSHA ASALIIFIED 480
CPKSLLVLYV DSMVKNLHSV LVIKLQELIR NGTKLALEQL VTTIASVADT IEEKFVPYYD 540
IFMPSLKHIV ELAVQKELKL LRGKTIECIS HIGLAVGKEK FMQDASNVMQ LLLKTQSDLN 600
NMEDDDPQTS YMVSAWARMC KILGKDFQQY LPLVIEPLIK TASAKPDVAL LDTQDVENMS 660
DDDGWQFVNL GDQQSFGIKT SGLEAKATAC QMLVYYAKEL REGFVEYTEQ VVKLMVPLLK 720
FYFHDNVRVA AAESMPFLLE CARIRGPEYL AQMWQFICDP LIKAIGTEPD TDVLSEIMNS 780
FAKSIEVMGD GCLNDEHLEE LGGILKAKLE GHFKNQELRQ VKRQEENYDQ QVEMSLQDED 840
ECDVYILTKV SDILHSLFST YKEKILPWFE QLLPLIVNLI CSSRPWPDRQ WGLCIFDDII 900
EHCSPTSFKY VEYFRWPMLL NMRDNNPEVR QAAAYGLGVM AQFGGDDYRS LCSEAVPLLV 960
KVIKCANSKT KKNVIATENC ISAIGKILKF KPNCVNVDEV LPHWLSWLPL HEDKEEAIQT 1020
LSFLCDLIES NHPVVIGPNN SNLPKIISII AEGKINETIN YEDPCAKRLA NVVRQVQTSE 1080
DLWLECVSQL DDEQQEALQE LLNFA 1105 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR000357; HEAT. 
Pfam
 PF02985; HEAT 
SMART
  
PROSITE
 PS50077; HEAT_REPEAT 
PRINTS