CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029133
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Aminopeptidase B 
Protein Synonyms/Alias
  
Gene Name
 RNPEP 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
161APEQTAGKKKPFVYTubiquitination[1, 2]
162PEQTAGKKKPFVYTQubiquitination[2, 3]
355GEENPLNKLRVKIEPubiquitination[1, 4]
359PLNKLRVKIEPGVDPubiquitination[2, 3, 4]
407KAYVHEFKFRSILADacetylation[5, 6]
407KAYVHEFKFRSILADubiquitination[2]
553QEDFWKVKEFLHNQGubiquitination[4]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [6] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 611 AA 
Protein Sequence
MASGEHSPGS GAARRPLHSA QAVDVASASN FRAFELLHLH LDLRAEFGPP GPGAGSRGLS 60
GTAVLDLRCL EPEGAAELRL DSHPCLEVTA AALRRERPGS EEPPAEPVSF YTQPFSHYGQ 120
ALCVSFPQPC RAAERLQVLL TYRVGEGPGV CWLAPEQTAG KKKPFVYTQG QAVLNRAFFP 180
CFDTPAVKYK YSALIEVPDG FTAVMSASTW EKRGPNKFFF QMCQPIPSYL IALAIGDLVS 240
AEVGPRYDLL FMPPSFPFGG MENPCLTFVT PCLLAGDRSL ADVIIHEISH SWFGNLVTNA 300
NWGEFWLNEG FTMYAQRRIS TILFGAAYTC LEAATGRALL RQHMDITGEE NPLNKLRVKI 360
EPGVDPDDTY NETPYEKGFC FVSYLAHLVG DQDQFDSFLK AYVHEFKFRS ILADDFLDFY 420
LEYFPELKKK RVDIIPGFEF DRWLNTPGWP PYLPDLSPGD SLMKPAEELA QLWAAEELDM 480
KAIEAVAISP WKTYQLVYFL DKILQKSPLP PGNVKKLGDT YPSISNARNA ELRLRWGQIV 540
LKNDHQEDFW KVKEFLHNQG KQKYTLPLYH AMMGGSEVAQ TLAKETFAST ASQLHSNVVN 600
YVQQIVAPKG S 611 
Gene Ontology
 GO:0005615; C:extracellular space; IEA:InterPro.
 GO:0004177; F:aminopeptidase activity; IEA:InterPro.
 GO:0008237; F:metallopeptidase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0019370; P:leukotriene biosynthetic process; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:InterPro. 
Interpro
 IPR016024; ARM-type_fold.
 IPR015571; Pept_M1_aminopeptidase-B.
 IPR001930; Peptidase_M1.
 IPR015211; Peptidase_M1_C.
 IPR014782; Peptidase_M1_N. 
Pfam
 PF09127; Leuk-A4-hydro_C
 PF01433; Peptidase_M1 
SMART
  
PROSITE
  
PRINTS
 PR00756; ALADIPTASE.