| Tag | Content |
|---|
| CPLM ID | CPLM-004924 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 3-ketoacyl-CoA thiolase |
Protein Synonyms/Alias | Acetyl-CoA acyltransferase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta |
Gene Name | fadA |
Gene Synonyms/Alias | oldA; b3845; JW5578 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 186 | ATQSAAFKNEIIPTG | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. Involved in the aerobic and anaerobic degradation of long-chain fatty acids. |
Sequence Annotation | ACT_SITE 91 91 Acyl-thioester intermediate (By
ACT_SITE 343 343 Proton acceptor (By similarity).
ACT_SITE 373 373 Proton acceptor (By similarity). |
Keyword | Acyltransferase; Complete proteome; Cytoplasm; Direct protein sequencing; Fatty acid metabolism; Lipid degradation; Lipid metabolism; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 387 AA |
Protein Sequence | MEQVVIVDAI RTPMGRSKGG AFRNVRAEDL SAHLMRSLLA RNPALEAAAL DDIYWGCVQQ 60
TLEQGFNIAR NAALLAEVPH SVPAVTVNRL CGSSMQALHD AARMIMTGDA QACLVGGVEH 120
MGHVPMSHGV DFHPGLSRNV AKAAGMMGLT AEMLARMHGI SREMQDAFAA RSHARAWAAT 180
QSAAFKNEII PTGGHDADGV LKQFNYDEVI RPETTVEALA TLRPAFDPVN GMVTAGTSSA 240
LSDGAAAMLV MSESRAHELG LKPRARVRSM AVVGCDPSIM GYGPVPASKL ALKKAGLSAS 300
DIGVFEMNEA FAAQILPCIK DLGLIEQIDE KINLNGGAIA LGHPLGCSGA RISTTLLNLM 360
ERKDVQFGLA TMCIGLGQGI ATVFERV 387 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0003988; F:acetyl-CoA C-acyltransferase activity; IEA:HAMAP. GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |