| Tag | Content |
|---|
| CPLM ID | CPLM-007635 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Nuclear receptor subfamily 2 group F member 6 |
Protein Synonyms/Alias | COUP transcription factor 3; COUP-TF3; V-erbA-related protein 2; EAR-2 |
Gene Name | Nr2f6 |
Gene Synonyms/Alias | Ear-2; Ear2; Erbal2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 278 | AFQEQVDKLGRLQVD | ubiquitination | [1] | | 366 | FFMRLVGKTPIETLI | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type- specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). |
Sequence Annotation | DNA_BIND 54 129 Nuclear receptor.
ZN_FING 57 77 NR C4-type.
ZN_FING 93 117 NR C4-type.
REGION 163 390 Ligand-binding (By similarity).
REGION 314 390 Important for dimerization (By
MOD_RES 41 41 Phosphoserine.
MOD_RES 84 84 Phosphoserine (By similarity). |
Keyword | Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Receptor; Reference proteome; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 390 AA |
Protein Sequence | MAMVTGGWGD PGGDTNGVDK AGGSYPRATE DDSASPPGAT SDAEPGDEER PGLQVDCVVC 60
GDKSSGKHYG VFTCEGCKSF FKRSIRRNLS YTCRSNRDCQ IDQHHRNQCQ YCRLKKCFRV 120
GMRKEAVQRG RIPHALPGPA ACSPPGATGV EPFTGPPVSE LIAQLLRAEP YPAAGRFGGG 180
GAVLGIDNVC ELAARLLFST VEWARHAPFF PELPAADQVA LLRLSWSELF VLNAAQAALP 240
LHTAPLLAAA GLHAAPMAAE RAVAFMDQVR AFQEQVDKLG RLQVDAAEYG CLKAIALFTP 300
DACGLSDPAH VESLQEKAQV ALTEYVRAQY PSQPQRFGRL LLRLPALRAV PASLISQLFF 360
MRLVGKTPIE TLIRDMLLSG STFNWPYGSG 390 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0004879; F:ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; IEA:InterPro. GO:0043565; F:sequence-specific DNA binding; IEA:Compara. GO:0003707; F:steroid hormone receptor activity; IEA:InterPro. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0050965; P:detection of temperature stimulus involved in sensory perception of pain; IMP:MGI. GO:0043153; P:entrainment of circadian clock by photoperiod; IMP:MGI. GO:0030522; P:intracellular receptor signaling pathway; IEA:GOC. GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara. GO:0048666; P:neuron development; IMP:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |