UniProt Accession

 SIVA_HUMAN; O15304; Q96P98; Q9UPD6 

Genbank Protein ID

 U82938; AF033111; BC034562; AF401214; BK000018 

Genbank Nucleotide ID

 AAC51372.1; AAD50057.1; AAH34562.1; AAL02171.1; DAA01049.1 

Protein Name

 Apoptosis regulatory protein Siva 

Protein Synonyms/Alias

 CD27-binding protein; CD27BP 

Gene Name

 SIVA1 

Gene Synonyms/Alias

 SIVA 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
17	DVAPLQLKVRVSQRE	ubiquitination	[1, 2, 3, 4]
41	YSQEVFEKTKRLLFL	ubiquitination	[3, 5]
43	QEVFEKTKRLLFLGA	ubiquitination	[3]
124	CVRAVDGKAVCGQCE	ubiquitination	[2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa- B and promotes T-cell receptor-mediated apoptosis. 

Sequence Annotation

 REGION 36 55 Interaction with BCL2L1 isoform Bcl-x(L)
 REGION 105 123 Interaction with coxsackievirus B3 VP2.
 MOD_RES 34 34 Phosphotyrosine; by ABL2.  

Keyword

 Alternative splicing; Apoptosis; Complete proteome; Cytoplasm; Host-virus interaction; Metal-binding; Nucleus; Pharmaceutical; Phosphoprotein; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 175 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:HGNC.
 GO:0005654; C:nucleoplasm; IDA:HGNC.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0001618; F:viral receptor activity; ISS:HGNC.
 GO:0008270; F:zinc ion binding; IDA:HGNC.
 GO:0006924; P:activation-induced cell death of T cells; IDA:HGNC.
 GO:0097191; P:extrinsic apoptotic signaling pathway; IDA:BHF-UCL.
 GO:0097193; P:intrinsic apoptotic signaling pathway; IDA:BHF-UCL.
 GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IDA:HGNC.
 GO:1901030; P:positive regulation of mitochondrial outer membrane permeabilization; IDA:BHF-UCL.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR022773; Siva_cd27-bd. 

Pfam

 PF05458; Siva 

SMART

  

PROSITE

  

PRINTS