CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042891
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 ATP-binding cassette sub-family F member 1 
Protein Synonyms/Alias
  
Gene Name
 ABCF1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
26ERQVASLKAANAAENubiquitination[1]
181GAAAAEAKARRILAGubiquitination[2]
202MQNRPTQKFSGGWRMubiquitination[3]
440MRKNHRLKIGFFNQQubiquitination[2, 3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 596 AA 
Protein Sequence
XAHLSKKEKK KLKKQMEYER QVASLKAANA AENDFSVSQA EMSSRQAMLE NASDIKLEKF 60
SISAHGKELF VNADLYIVAG RRYGLVGPNG KGKTTLLKHI ANRALSIPPN IDVLLCEQEV 120
VADETPAVQA VLRADTKRLK LLEEERRLQG QLEQGDDTAA ERLEKVYEEL RATGAAAAEA 180
KARRILAGLG FDPEMQNRPT QKFSGGWRMR VSLARALFME PTLLMLDEPT NHLDLNAVIW 240
LNNYLQGWRK TLLIVSHDQG FLDDVCTDII HLDAQRLHYY RGNYMTFKKM YQQKQKELLK 300
QYEKQEKKLK ELKAGGKSTK QAEKQTKEAL TRKQQKCRRK NQDEESQEAP ELLKRPKEYT 360
VRFTFPDPPP LSPPVLGLHG VTFGYQGQKP LFKNLDFGID MDSRICIVGP NGVGKSTLLL 420
LLTGKLTPTH GEMRKNHRLK IGFFNQQYAE QLRMEETPTE YLQRGFNLPY QDARKCLGRF 480
GLESHAHTIQ ICKLSGGQKA RVVFAELACR EPDVLILDEP TNNLDIESID ALGEAINEYK 540
GAVIVVSHDA RLITETNCQL WVVEEQSVSQ IDGDFEDYKR EVLEALGEVM VSRPRE 596 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; IEA:InterPro.
 GO:0006200; P:ATP catabolic process; IEA:GOC. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS