UniProt Accession

 TXND5_HUMAN; Q8NBS9; B2RDM2; Q5TCQ0; Q8ND33; Q8TCT2; Q9BVH9 

Genbank Protein ID

 AY358646; AK075291; AK315598; AL023694; AL096800; AL133541; CH471087; AJ440721; BC001199; AL834423 

Genbank Nucleotide ID

 AAQ89009.1; BAC11526.1; BAG37969.1; CAI19473.1; EAW55221.1; CAD29430.1; AAH01199.1; CAD39084.1 

Protein Name

 Thioredoxin domain-containing protein 5 

Protein Synonyms/Alias

 Endoplasmic reticulum resident protein 46; ER protein 46; ERp46; Thioredoxin-like protein p46 

Gene Name

 TXNDC5 

Gene Synonyms/Alias

 TLP46; UNQ364/PRO700 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
113	YNSMEDAKVYVAKVD	ubiquitination	[1, 2]
118	DAKVYVAKVDCTAHS	ubiquitination	[3]
143	YPTLKLFKPGQEAVK	ubiquitination	[3]
150	KPGQEAVKYQGPRDF	ubiquitination	[1, 2]
244	SETVKIGKVDCTQHY	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide- isomerase deficiency in yeast (By similarity). 

Sequence Annotation

 DOMAIN 36 169 Thioredoxin 1.
 DOMAIN 170 295 Thioredoxin 2.
 DOMAIN 304 429 Thioredoxin 3.
 MOTIF 429 432 Prevents secretion from ER (Potential).
 DISULFID 89 92 Redox-active (Potential).
 DISULFID 217 220 Redox-active (Potential).
 DISULFID 350 353 Redox-active (Potential).  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Disulfide bond; Endoplasmic reticulum; Redox-active center; Reference proteome; Repeat; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 432 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; TAS:UniProtKB.
 GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
 GO:0043202; C:lysosomal lumen; TAS:Reactome.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0016853; F:isomerase activity; IEA:InterPro.
 GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro.
 GO:0016044; P:cellular membrane organization; TAS:Reactome.
 GO:0006662; P:glycerol ether metabolic process; IEA:InterPro.
 GO:0043066; P:negative regulation of apoptotic process; TAS:UniProtKB.
 GO:0006892; P:post-Golgi vesicle-mediated transport; TAS:Reactome. 

Interpro

 IPR005788; Disulphide_isomerase.
 IPR005746; Thioredoxin.
 IPR012336; Thioredoxin-like_fold.
 IPR017937; Thioredoxin_CS.
 IPR013766; Thioredoxin_domain. 

Pfam

 PF00085; Thioredoxin 

SMART

  

PROSITE

 PS00014; ER_TARGET
 PS00194; THIOREDOXIN_1
 PS51352; THIOREDOXIN_2 

PRINTS

 PR00421; THIOREDOXIN.