UniProt Accession

 HAND2_RAT; P61295; O95300; O95301; P97833 

Genbank Protein ID

 Y08138 

Genbank Nucleotide ID

 CAA69332.1 

Protein Name

 Heart- and neural crest derivatives-expressed protein 2 

Protein Synonyms/Alias

 Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2; dHAND 

Gene Name

 Hand2 

Gene Synonyms/Alias

 Dhand 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
183	VKEEKRKKELNEILK	ubiquitination	[1]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity). 

Sequence Annotation

 DOMAIN 99 151 bHLH.  

Keyword

 Angiogenesis; Complete proteome; Developmental protein; Differentiation; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 217 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IC:BHF-UCL.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0019904; F:protein domain specific binding; IDA:RGD.
 GO:0003713; F:transcription coactivator activity; IMP:BHF-UCL.
 GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0071407; P:cellular response to organic cyclic compound; IEP:RGD.
 GO:0071300; P:cellular response to retinoic acid; IEP:RGD.
 GO:0007507; P:heart development; IEP:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:RGD.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR011598; bHLH_dom. 

Pfam

 PF00010; HLH 

SMART

 SM00353; HLH 

PROSITE

 PS50888; BHLH 

PRINTS