CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038055
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Phosphorylase 
Protein Synonyms/Alias
  
Gene Name
 Pygm 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
10RPLSDQDKRKQISVRubiquitination[1]
29VENVSELKKNFNRHLubiquitination[1]
42HLHFTLVKDRNVATPubiquitination[1]
160TMRLWSAKAPNDFNLubiquitination[1]
202NDNFFEGKELRLKQEacetylation[2]
202NDNFFEGKELRLKQEubiquitination[1]
228IRRFKSSKFGSRDPVubiquitination[1]
276LERLDWDKAWDVTVKubiquitination[1]
395EPHKFQNKTNGITPRubiquitination[1]
433SDLDQLRKLLSYVDDubiquitination[1]
530APGYHMAKMIIKLITubiquitination[1]
568YRVSLAEKVIPAADLubiquitination[1]
666SSGFFSPKQPDLFKDubiquitination[1]
695ADYEEYIKCQDKVSEubiquitination[1]
723RNIATSGKFSSDRTIubiquitination[1]
753RLPAPDEKI******ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758] 
Functional Description
 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity). 
Sequence Annotation
  
Keyword
 Carbohydrate metabolism; Complete proteome; Glycosyltransferase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 754 AA 
Protein Sequence
MSRPLSDQDK RKQISVRGLA GVENVSELKK NFNRHLHFTL VKDRNVATPR DYYFALAHTV 60
RDHLVGRWIR TQQHYYEKDP KKICGGWQME EADDWLRYGN PWEKARPEFT LPVHFYGRVE 120
HTSQGAKWVD TQVVLAMPYD TPVPGYRNNV VNTMRLWSAK APNDFNLKDF NVGGYIQAVL 180
DRNLAENISR VLYPNDNFFE GKELRLKQEY FVVAATLQDI IRRFKSSKFG SRDPVRTNFD 240
AFPDKVAIQL NDTHPSLAIP ELMRILVDLE RLDWDKAWDV TVKTCAYTNH TVLPEALERW 300
PVHLMETLLP RHLQIIYEIN QRFLNRVAAA FPGDVDRLRR MSLVEEGAVK RINMAHLCIA 360
GSHAVNGVAR IHSEILKKTI FKDFYELEPH KFQNKTNGIT PRRWLVLCNP GLAEVIAERI 420
GEDYISDLDQ LRKLLSYVDD EAFIRDVAKV KQENKLKFSA YLEREYKVHI NPNSLFDVQV 480
KRIHEYKRQL LNCLHIITLY NRIKREPNRF MVPRTIMIGG KAAPGYHMAK MIIKLITAIG 540
DVVNHDPAVG DRLRVIFLEN YRVSLAEKVI PAADLSEQIS TAGTEASGTG NMKFMLNGAL 600
TIGTMDGANV EMAEEAGEEN FFIFGMRVED VERLDQRGYN AQEYYDRIPE LRQIIEQLSS 660
GFFSPKQPDL FKDIVNMLMH HDRFKVFADY EEYIKCQDKV SELYKNPREW TRMVIRNIAT 720
SGKFSSDRTI AQYAREIWGV EPSRQRLPAP DEKI 754 
Gene Ontology
 GO:0008184; F:glycogen phosphorylase activity; IDA:MGI.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0005980; P:glycogen catabolic process; IDA:MGI. 
Interpro
 IPR011833; Glycg_phsphrylas.
 IPR000811; Glyco_trans_35. 
Pfam
 PF00343; Phosphorylase 
SMART
  
PROSITE
 PS00102; PHOSPHORYLASE 
PRINTS