| Tag | Content |
|---|
| CPLM ID | CPLM-010946 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ankyrin-1 |
Protein Synonyms/Alias | ANK-1; Erythrocyte ankyrin |
Gene Name | Ank1 |
Gene Synonyms/Alias | Ank-1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 92 | ASKEGHVKMVVELLH | ubiquitination | [1] | | 202 | HLINYGTKGKVRLPA | ubiquitination | [1] | | 303 | AQIETRTKDELTPLH | ubiquitination | [1] | | 336 | APIQAKTKNGLSPIH | ubiquitination | [1] | | 388 | CGHHRVAKVLLDKGA | ubiquitination | [1] | | 487 | AGHTEVAKYLLQNKA | ubiquitination | [1] | | 578 | TPLHVAAKYGKVRLA | ubiquitination | [1] | | 644 | TPLHIAAKQNQIEVA | ubiquitination | [1] | | 699 | ANGNLGNKSGLTPLH | ubiquitination | [1] | | 722 | PVADVLIKHGVTVDA | ubiquitination | [1] | | 834 | SVVLVSDKHRMSYPE | ubiquitination | [1] | | 890 | ELLDFVPKLDQVVES | ubiquitination | [1] | | 999 | CRLVKPQKLNTPPPL | ubiquitination | [1] | | 1143 | FPENAVTKKVKLALQ | ubiquitination | [1] | | 1146 | NAVTKKVKLALQAQP | ubiquitination | [1] | | 1288 | AKFVIFAKMNDAREG | ubiquitination | [1] | | 1369 | NRLAIPVKVRDSSRE | ubiquitination | [1] | | 1504 | DREGENAKMENLYTA | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. In skeletal muscle, isoform Mu7 together with obscurin may provide a molecular link between the sarcoplasmic reticulum and myofibrils. |
Sequence Annotation | REPEAT 40 69 ANK 1.
REPEAT 73 102 ANK 2.
REPEAT 106 135 ANK 3.
REPEAT 139 168 ANK 4.
REPEAT 170 197 ANK 5.
REPEAT 201 230 ANK 6.
REPEAT 234 263 ANK 7.
REPEAT 267 296 ANK 8.
REPEAT 300 329 ANK 9.
REPEAT 333 362 ANK 10.
REPEAT 366 395 ANK 11.
REPEAT 399 428 ANK 12.
REPEAT 432 461 ANK 13.
REPEAT 465 494 ANK 14.
REPEAT 498 527 ANK 15.
REPEAT 531 560 ANK 16.
REPEAT 564 593 ANK 17.
REPEAT 597 626 ANK 18.
REPEAT 630 659 ANK 19.
REPEAT 663 692 ANK 20.
REPEAT 696 725 ANK 21.
REPEAT 729 758 ANK 22.
REPEAT 762 791 ANK 23.
DOMAIN 907 1032 ZU5 1.
DOMAIN 1033 1196 ZU5 2.
DOMAIN 1399 1483 Death.
REGION 1 827 89 kDa domain.
REGION 1197 1331 UPA domain (By similarity).
REGION 1387 1862 55 kDa regulatory domain.
MOD_RES 101 101 (3S)-3-hydroxyasparagine; by HIF1AN;
MOD_RES 229 229 (3S)-3-hydroxyasparagine; by HIF1AN (By
MOD_RES 427 427 (3S)-3-hydroxyasparagine; by HIF1AN (By
MOD_RES 460 460 (3S)-3-hydroxyasparagine; by HIF1AN (By
MOD_RES 625 625 (3S)-3-hydroxyasparagine; by HIF1AN (By
MOD_RES 658 658 (3S)-3-hydroxyasparagine; by HIF1AN (By
MOD_RES 691 691 (3S)-3-hydroxyaspartate; by HIF1AN (By
MOD_RES 724 724 (3S)-3-hydroxyasparagine; by HIF1AN (By
MOD_RES 757 757 (3S)-3-hydroxyasparagine; by HIF1AN (By
MOD_RES 852 852 Phosphoserine.
MOD_RES 862 862 Phosphothreonine.
MOD_RES 1069 1069 Phosphotyrosine. |
Keyword | Alternative promoter usage; Alternative splicing; ANK repeat; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Hydroxylation; Lipoprotein; Membrane; Phosphoprotein; Reference proteome; Repeat; Sarcoplasmic reticulum. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1862 AA |
Protein Sequence | MAQAAKQLKK IKDIEAQALQ EQKEKEESNR KRRNRSRDRK KKADAATSFL RAARSGNLDK 60
ALDHLRNGVD INTCNQNGLN GLHLASKEGH VKMVVELLHK EIILETTTKK GNTALHIAAL 120
AGQDEVVREL VNYGANVNAQ SQKGFTPLYM AAQENHLEVV KFLLENGANQ NVATEDGFTP 180
LAVALQQGHE NVVAHLINYG TKGKVRLPAL HIAARNDDTR TAAVLLQNDP NPDVLSKTGF 240
TPLHIAAHYE NLNVAQLLLN RGASVNFTPQ NGITPLHIAS RRGNVIMVRL LLDRGAQIET 300
RTKDELTPLH CAARNGHVRI SEILLDHGAP IQAKTKNGLS PIHMAAQGDH LDCVRLLLQY 360
NAEIDDITLD HLTPLHVAAH CGHHRVAKVL LDKGAKPNSR ALNGFTPLHI ACKKNHIRVM 420
ELLLKTGASI DAVTESGLTP LHVASFMGHL PIVKNLLQRG ASPNVSNVKV ETPLHMAARA 480
GHTEVAKYLL QNKAKANAKA KDDQTPLHCA ARIGHTGMVK LLLENGASPN LATTAGHTPL 540
HTAAREGHVD TALALLEKEA SQACMTKKGF TPLHVAAKYG KVRLAELLLE HDAHPNAAGK 600
NGLTPLHVAV HHNNLDIVKL LLPRGGSPHS PAWNGYTPLH IAAKQNQIEV ARSLLQYGGS 660
ANAESVQGVT PLHLAAQEGH TEMVALLLSK QANGNLGNKS GLTPLHLVSQ EGHVPVADVL 720
IKHGVTVDAT TRMGYTPLHV ASHYGNIKLV KFLLQHQADV NAKTKLGYSP LHQAAQQGHT 780
DIVTLLLKNG ASPNEVSSNG TTPLAIAKRL GYISVTDVLK VVTDETSVVL VSDKHRMSYP 840
ETVDEILDVS EDEGTAHISI MGDELVGSKA ERRDSRDVGE EKELLDFVPK LDQVVESPAI 900
PRIPCVTPET VVIRSEDQEQ ASKEYDEDSL IPSSPATETS DNISPVASPV HTGFLVSFMV 960
DARGGSMRGS RHNGLRVVIP PRTCAAPTRI TCRLVKPQKL NTPPPLAEEE GLASRIIALG 1020
PTGAQFLSPV IVEIPHFASH GRGDRELVVL RSENGSVWKE HKSRYGESYL DQILNGMDEE 1080
LGSLEELEKK RVCRIITTDF PLYFVIMSRL CQDYDTIGPE GGSLRSKLVP LVQATFPENA 1140
VTKKVKLALQ AQPVPDELVT KLLGNQATFS PIVTVEPRRR KFHRPIGLRI PLPPSWTDNP 1200
RDSGEGDTTS LRLLCSVIGG TDQAQWEDIT GTTKLIYANE CANFTTNVSA RFWLSDCPRT 1260
AEAVHFATLL YKELTAVPYM AKFVIFAKMN DAREGRLRCY CMTDDKVDKT LEQHENFVEV 1320
ARSRDIEVLE GMPLFAELSG NLVPVKKAAQ QRSFHFQSFR ENRLAIPVKV RDSSREPGGF 1380
LSFLRKTMKY EDTQHILCHL NITMPPCTKG SGAEDRRRTL TPLTLRYSIL SESRLGFTSD 1440
TDRVEMRMAV IREHLGLSWA ELARELQFSV EDINRIRVEN PNSLLDQSTA LLTLWVDREG 1500
ENAKMENLYT ALRNIDRSEI VNMLEGSGRQ SRNLKPERRH GDREYSLSPS QVNGYSSLQD 1560
ELLSPASLQY ALPSPLCADQ YWNEVTVIDA IPLAATEHDT MLEMSDMQVW SAGLTPSLVT 1620
AEDSSLECSK AEDSDAIPEW KLEGAHSEDT QGPELGSQDL VEDDTVDSDA TNGLADLLGQ 1680
EEGQRSEKKR QEVSGTEQDT ETEVSLVSGQ QRVHARITDS PSVRQVLDRS QARTLDWDKQ 1740
GSTAVHPQEA TQSSWQEEVT QGPHSFQRRI TTIQGPEPGA LQEYEQVLVS TREHVQRGPP 1800
ETGSPKAGKE PSLWAPESAF SQEVQGDELQ NIPGEQVTEE QFTDEQGNIV TKKIIRKVVR 1860
QVDSSGAIDT QQHEEVELRG SGLQPDLIEG RKGAQIVKRA SLKRGKQ 1907 |
Gene Ontology | GO:0030863; C:cortical cytoskeleton; IDA:MGI. GO:0016020; C:membrane; IDA:MGI. GO:0005886; C:plasma membrane; IEA:Compara. GO:0016529; C:sarcoplasmic reticulum; IEA:UniProtKB-SubCell. GO:0014731; C:spectrin-associated cytoskeleton; IMP:MGI. GO:0006888; P:ER to Golgi vesicle-mediated transport; IEA:Compara. GO:0048821; P:erythrocyte development; IMP:MGI. GO:0015672; P:monovalent inorganic cation transport; IMP:MGI. GO:0006779; P:porphyrin-containing compound biosynthetic process; IMP:MGI. GO:0072661; P:protein targeting to plasma membrane; IEA:Compara. GO:0007165; P:signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |