CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005152
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein MalY 
Protein Synonyms/Alias
 Cystathionine beta-lyase MalY; CBL; Beta-cystathionase; Cysteine lyase; Maltose regulon modulator 
Gene Name
 malY 
Gene Synonyms/Alias
 b1622; JW1614 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
126PAYDAFYKAIEGNQRacetylation[1]
261DAYLSALKGRDGLSSacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Acts as a beta-cystathionase and as a repressor of the maltose regulon. 
Sequence Annotation
 MOD_RES 233 233 N6-(pyridoxal phosphate)lysine.  
Keyword
 3D-structure; Amino-acid biosynthesis; Complete proteome; Lyase; Methionine biosynthesis; Pyridoxal phosphate; Reference proteome; Repressor; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 390 AA 
Protein Sequence
MFDFSKVVDR HGTWCTQWDY VADRFGTADL LPFTISDMDF ATAPCIIEAL NQRLMHGVFG 60
YSRWKNDEFL AAIAHWFSTQ HYTAIDSQTV VYGPSVIYMV SELIRQWSET GEGVVIHTPA 120
YDAFYKAIEG NQRTVMPVAL EKQADGWFCD MGKLEAVLAK PECKIMLLCS PQNPTGKVWT 180
CDELEIMADL CERHGVRVIS DEIHMDMVWG EQPHIPWSNV ARGDWALLTS GSKSFNIPAL 240
TGAYGIIENS SSRDAYLSAL KGRDGLSSPS VLALTAHIAA YQQGAPWLDA LRIYLKDNLT 300
YIADKMNAAF PELNWQIPQS TYLAWLDLRP LNIDDNALQK ALIEQEKVAI MPGYTYGEEG 360
RGFVRLNAGC PRSKLEKGVA GLINAIRAVR 390 
Gene Ontology
 GO:0004121; F:cystathionine beta-lyase activity; IDA:EcoCyc.
 GO:0080146; F:L-cysteine desulfhydrase activity; IMP:EcoCyc.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IDA:EcoCyc. 
Interpro
 IPR004839; Aminotransferase_I/II.
 IPR027619; C_S_lyase_PatB.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 
Pfam
 PF00155; Aminotran_1_2 
SMART
  
PROSITE
 PS00599; AA_TRANSFER_CLASS_2 
PRINTS