CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017530
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Activating signal cointegrator 1 complex subunit 1 
Protein Synonyms/Alias
 ASC-1 complex subunit p50; Trip4 complex subunit p50 
Gene Name
 ASCC1 
Gene Synonyms/Alias
 CGI-18 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
82GKRGDTRKKIEMETKacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. 
Sequence Annotation
 DOMAIN 86 148 KH.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Polymorphism; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 400 AA 
Protein Sequence
MEVLRPQLIR IDGRNYRKNP VQEQTYQHEE DEEDFYQGSM ECADEPCDAY EVEQTPQGFR 60
STLRAPSLLY KHIVGKRGDT RKKIEMETKT SISIPKPGQD GEIVITGQHR NGVISARTRI 120
DVLLDTFRRK QPFTHFLAFF LNEVEVQEGF LRFQEEVLAK CSMDHGVDSS IFQNPKKLHL 180
TIGMLVLLSE EEIQQTCEML QQCKEEFIND ISGGKPLEVE MAGIEYMNDD PGMVDVLYAK 240
VHMKDGSNRL QELVDRVLER FQASGLIVKE WNSVKLHATV MNTLFRKDPN AEGRYNLYTA 300
EGKYIFKERE SFDGRNILKL FENFYFGSLK LNSIHISQRF TVDSFGNYAS CGQIDFS 357 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005667; C:transcription factor complex; IDA:MGI.
 GO:0003824; F:catalytic activity; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IDA:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR009210; Euk_LigT.
 IPR004087; KH_dom.
 IPR004088; KH_dom_type_1.
 IPR019510; Kinase-A_anchor_nucl_local_sig.
 IPR009097; RNA_ligase/cNuc_Pdiesterase. 
Pfam
 PF10469; AKAP7_NLS
 PF00013; KH_1 
SMART
 SM00322; KH 
PROSITE
 PS50084; KH_TYPE_1 
PRINTS