UniProt Accession

 SRRM1_HUMAN; Q8IYB3; O60585; Q5VVN4 

Genbank Protein ID

 AF048977; AF419855; AL445648; AL445686; AL445686; AL445648; BC036187 

Genbank Nucleotide ID

 AAC09321.1; AAP97290.1; CAH73090.1; CAH73090.1; CAI14682.1; CAI14682.1; AAH36187.1 

Protein Name

 Serine/arginine repetitive matrix protein 1 

Protein Synonyms/Alias

 SR-related nuclear matrix protein of 160 kDa; SRm160; Ser/Arg-related nuclear matrix protein 

Gene Name

 SRRM1 

Gene Synonyms/Alias

 SRM160 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
49	KVNLEVIKPWITKRV	ubiquitination	[1]
54	VIKPWITKRVTEILG	ubiquitination	[1]
140	QRQIEQEKLASMKKQ	acetylation	[2]
425	QQSNRTRKSRVSVSP	methylation	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] Mass spectrometry-based identification and characterisation of lysine and arginine methylation in the human proteome.
 Bremang M, Cuomo A, Agresta AM, Stugiewicz M, Spadotto V, Bonaldi T.
 Mol Biosyst. 2013 Jul 30;9(9):2231-47. [PMID: 23748837] 

Functional Description

 Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. 

Sequence Annotation

 DOMAIN 27 126 PWI.
 REGION 1 156 Necessary for mRNA 3'-end cleavage and
 REGION 1 151 Necessary for DNA and RNA-binding.
 REGION 300 688 Necessary for speckles and matrix
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 140 140 N6-acetyllysine.
 MOD_RES 207 207 Phosphoserine (By similarity).
 MOD_RES 209 209 Phosphoserine (By similarity).
 MOD_RES 211 211 Phosphoserine (By similarity).
 MOD_RES 220 220 Phosphothreonine.
 MOD_RES 227 227 Phosphoserine.
 MOD_RES 234 234 Phosphoserine.
 MOD_RES 260 260 Phosphoserine.
 MOD_RES 389 389 Phosphoserine.
 MOD_RES 391 391 Phosphoserine.
 MOD_RES 393 393 Phosphoserine.
 MOD_RES 402 402 Phosphoserine.
 MOD_RES 406 406 Phosphothreonine.
 MOD_RES 414 414 Phosphoserine.
 MOD_RES 416 416 Phosphothreonine.
 MOD_RES 420 420 Phosphoserine.
 MOD_RES 429 429 Phosphoserine.
 MOD_RES 431 431 Phosphoserine.
 MOD_RES 436 436 Phosphoserine.
 MOD_RES 450 450 Phosphoserine.
 MOD_RES 452 452 Phosphoserine.
 MOD_RES 463 463 Phosphoserine.
 MOD_RES 465 465 Phosphoserine.
 MOD_RES 478 478 Phosphoserine.
 MOD_RES 549 549 Phosphoserine.
 MOD_RES 551 551 Phosphoserine.
 MOD_RES 555 555 Phosphothreonine.
 MOD_RES 560 560 Phosphoserine.
 MOD_RES 562 562 Phosphoserine.
 MOD_RES 572 572 Phosphothreonine.
 MOD_RES 574 574 Phosphothreonine.
 MOD_RES 581 581 Phosphothreonine.
 MOD_RES 583 583 Phosphoserine.
 MOD_RES 597 597 Phosphoserine.
 MOD_RES 605 605 Phosphoserine.
 MOD_RES 607 607 Phosphoserine.
 MOD_RES 614 614 Phosphothreonine.
 MOD_RES 616 616 Phosphoserine.
 MOD_RES 626 626 Phosphoserine.
 MOD_RES 628 628 Phosphoserine.
 MOD_RES 636 636 Phosphoserine.
 MOD_RES 638 638 Phosphoserine.
 MOD_RES 646 646 Phosphoserine.
 MOD_RES 653 653 Phosphoserine (By similarity).
 MOD_RES 675 675 Phosphoserine (By similarity).
 MOD_RES 683 683 Phosphoserine (By similarity).
 MOD_RES 685 685 Phosphoserine (By similarity).
 MOD_RES 694 694 Phosphoserine.
 MOD_RES 696 696 Phosphoserine.
 MOD_RES 705 705 Phosphoserine.
 MOD_RES 707 707 Phosphoserine.
 MOD_RES 713 713 Phosphoserine.
 MOD_RES 715 715 Phosphoserine.
 MOD_RES 738 738 Phosphoserine.
 MOD_RES 740 740 Phosphoserine.
 MOD_RES 743 743 Phosphoserine (By similarity).
 MOD_RES 748 748 Phosphoserine.
 MOD_RES 752 752 Phosphoserine.
 MOD_RES 754 754 Phosphoserine.
 MOD_RES 756 756 Phosphoserine.
 MOD_RES 769 769 Phosphoserine.
 MOD_RES 773 773 Phosphoserine (By similarity).
 MOD_RES 775 775 Phosphoserine.
 MOD_RES 777 777 Phosphoserine.
 MOD_RES 781 781 Phosphoserine.
 MOD_RES 791 791 Phosphoserine.
 MOD_RES 793 793 Phosphothreonine.
 MOD_RES 795 795 Phosphoserine.
 MOD_RES 872 872 Phosphothreonine.
 MOD_RES 874 874 Phosphoserine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; DNA-binding; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; RNA-binding; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 904 AA 

Protein Sequence

Gene Ontology

 GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
 GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0031124; P:mRNA 3'-end processing; TAS:Reactome.
 GO:0006406; P:mRNA export from nucleus; TAS:Reactome.
 GO:0000398; P:mRNA splicing, via spliceosome; IC:UniProtKB.
 GO:0006369; P:termination of RNA polymerase II transcription; TAS:Reactome. 

Interpro

 IPR002483; PWI_dom. 

Pfam

 PF01480; PWI 

SMART

 SM00311; PWI 

PROSITE

 PS51025; PWI 

PRINTS