UniProt Accession

 ZNF24_HUMAN; P17028; O14754; Q53YE4; Q6ICR5; Q8IZN4 

Genbank Protein ID

 U68536; AF016052; AF542097; AF038964; AK291246; BT006658; CR450328; AC116447; CH471088; CH471088; BC003566; BC016801; X52348 

Genbank Nucleotide ID

 AAB37275.1; AAB70216.1; AAN40767.1; AAD19827.1; BAF83935.1; AAP35304.1; CAG29324.1; EAX01348.1; EAX01349.1; AAH03566.1; AAH16801.1; CAA36574.1 

Protein Name

 Zinc finger protein 24 

Protein Synonyms/Alias

 Retinoic acid suppression protein A; RSG-A; Zinc finger and SCAN domain-containing protein 3; Zinc finger protein 191; Zinc finger protein KOX17 

Gene Name

 ZNF24 

Gene Synonyms/Alias

 KOX17; ZNF191; ZSCAN3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
27	EEKILRVKLEEDPDG	ubiquitination	[1, 2]
236	YGETCFPKGRFERKR	ubiquitination	[2]
286	YGCVECGKAFSRSSI	ubiquitination	[2, 3]
308	HTGEKPYKCLECGKA	ubiquitination	[2]
333	QRIHTGEKPYECVQC	ubiquitination	[2]
361	QRRHNAEKLLNVVKV	methylation	[4]
367	EKLLNVVKV******	ubiquitination	[3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510] 

Functional Description

 Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro. 

Sequence Annotation

 DOMAIN 52 134 SCAN box.
 ZN_FING 251 273 C2H2-type 1.
 ZN_FING 279 301 C2H2-type 2.
 ZN_FING 307 329 C2H2-type 3.
 ZN_FING 335 357 C2H2-type 4.
 MOD_RES 132 132 Phosphoserine.
 MOD_RES 142 142 Phosphoserine.
 MOD_RES 274 274 Phosphoserine.
 MOD_RES 335 335 Phosphotyrosine.  

Keyword

 3D-structure; Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 368 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; NAS:UniProtKB.
 GO:0042552; P:myelination; ISS:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0016032; P:viral reproduction; IEA:InterPro. 

Interpro

 IPR008916; Retrov_capsid_C.
 IPR003309; Tscrpt_reg_SCAN.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 

Pfam

 PF02023; SCAN 

SMART

 SM00431; SCAN
 SM00355; ZnF_C2H2 

PROSITE

 PS50804; SCAN_BOX
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 

PRINTS