CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041071
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Serpin B6 
Protein Synonyms/Alias
  
Gene Name
 Serpinb6a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
121ANRLFGDKTCDLLASubiquitination[1]
198YFKGNWEKQFNKEHTubiquitination[1]
218KVSKNEEKPVQMMFKacetylation[2, 3]
225KPVQMMFKKSTFKMTacetylation[2]
230MFKKSTFKMTYIGEIacetylation[2]
275EKEVTYEKFIEWTRLacetylation[2]
296EVEVFLPKFKLEENYacetylation[2]
298EVFLPKFKLEENYNMacetylation[2]
298EVFLPKFKLEENYNMubiquitination[1]
311NMNDALYKLGMTDAFacetylation[2]
330DFSGMSSKQGLFLSKacetylation[2]
337KQGLFLSKVVHKAFVacetylation[2]
341FLSKVVHKAFVEVNEacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 399 AA 
Protein Sequence
MGAARSRPGC CAGPRGYRLT IMDPLQEANG TFALNLLKIL GEDSSKNVFL SPMSISSALA 60
MVFMGAKGTT ASQMAQALAL DKCSGNGGGD VHQGFQSLLT EVNKTGTQYL LRTANRLFGD 120
KTCDLLASFK DSCLKFYEAE LEELDFQGAT EESRQHINTW VAKKTEDKIK EVLSPGTVNS 180
DTSLVLVNAI YFKGNWEKQF NKEHTREMPF KVSKNEEKPV QMMFKKSTFK MTYIGEIFTK 240
ILLLPYVSSE LNMIIMLPDE HVELSTVEKE VTYEKFIEWT RLDKMDEEEV EVFLPKFKLE 300
ENYNMNDALY KLGMTDAFGG RADFSGMSSK QGLFLSKVVH KAFVEVNEEG TEAAAATAGM 360
MTVRCMRFTP RFCADHPFLF FIHHVKTNGI LFCGRFSSP 399 
Gene Ontology
 GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:RefGenome.
 GO:0030162; P:regulation of proteolysis; IBA:RefGenome. 
Interpro
 IPR023795; Protease_inhib_I4_serpin_CS.
 IPR023796; Serpin_dom.
 IPR000215; Serpin_fam. 
Pfam
 PF00079; Serpin 
SMART
 SM00093; SERPIN 
PROSITE
 PS00284; SERPIN 
PRINTS