UniProt Accession

 PAIRB_MOUSE; Q9CY58; Q8BHS2; Q8BHU0; Q91WP3; Q9CSN0; Q9DBY6 

Genbank Protein ID

 AK004678; AK010860; AK012390; AK045190; AK088278; BC013665; BC030502 

Genbank Nucleotide ID

 BAB23466.1; BAB27229.1; BAB28207.1; BAC32255.1; BAC40253.1; AAH13665.1; AAH30502.1 

Protein Name

 Plasminogen activator inhibitor 1 RNA-binding protein 

Protein Synonyms/Alias

 PAI1 RNA-binding protein 1; PAI-RBP1; SERPINE1 mRNA-binding protein 1 

Gene Name

 Serbp1 

Gene Synonyms/Alias

 Pairbp1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
32	SDPFEVLKAAENKKK	ubiquitination	[1]
52	GVGGPGAKSAAQAAA	acetylation	[2]
68	TNSNAAGKQLRKESQ	acetylation	[2]
68	TNSNAAGKQLRKESQ	succinylation	[2]
68	TNSNAAGKQLRKESQ	ubiquitination	[1]
122	QQLQGDGKLIDRRAE	acetylation	[2, 3]
122	QQLQGDGKLIDRRAE	ubiquitination	[1]
236	DELTESPKYIQKQIS	ubiquitination	[1]
293	EMTLDEWKAIQNKDR	acetylation	[4]
293	EMTLDEWKAIQNKDR	ubiquitination	[1]
319	EGADGQWKKGFVLHK	ubiquitination	[1]
328	GFVLHKSKSEEAHAE	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (By similarity). 

Sequence Annotation

 MOD_RES 25 25 Phosphoserine.
 MOD_RES 68 68 N6-acetyllysine (By similarity).
 MOD_RES 122 122 N6-acetyllysine (By similarity).
 MOD_RES 140 140 N6-acetyllysine (By similarity).
 MOD_RES 211 211 N6-acetyllysine (By similarity).
 MOD_RES 234 234 Phosphoserine.
 MOD_RES 244 244 Phosphotyrosine.
 MOD_RES 252 252 Phosphoserine.
 MOD_RES 329 329 Phosphoserine.
 MOD_RES 390 390 Phosphoserine.
 MOD_RES 391 391 Phosphoserine (By similarity).
 MOD_RES 393 393 Phosphoserine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 407 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0003730; F:mRNA 3'-UTR binding; ISS:HGNC. 

Interpro

 IPR006861; HABP4_PAIRBP1-bd.
 IPR027205; SERBP1. 

Pfam

 PF04774; HABP4_PAI-RBP1 

SMART

  

PROSITE

  

PRINTS