UniProt Accession

 KBTB8_HUMAN; Q8NFY9; Q96JI5 

Genbank Protein ID

 AK096640; AC020655; AF385438; BC117487; AB058745 

Genbank Nucleotide ID

 AAM43839.1; AAI17488.1; BAB47471.1 

Protein Name

 Kelch repeat and BTB domain-containing protein 8 

Protein Synonyms/Alias

 T-cell activation kelch repeat protein; TA-KRP 

Gene Name

 KBTBD8 

Gene Synonyms/Alias

 KIAA1842; TAKRP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
238	HLPEIFAKCIRFPLM	ubiquitination	[1]
268	IAKSCVEKGPSNTNG	ubiquitination	[1]
301	AHKHSGKKQTVPCLD	ubiquitination	[1]
373	STNRWLSKPSLLRAR	ubiquitination	[1]
384	LRARIGCKLVYCCGK	ubiquitination	[1]
409	GDGRNSLKSVECYDS	ubiquitination	[1, 2]
599	LYPQCLQKVL*****	ubiquitination	[3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

  

Sequence Annotation

 DOMAIN 49 117 BTB.
 DOMAIN 152 254 BACK.
 REPEAT 336 390 Kelch 1.
 REPEAT 391 441 Kelch 2.
 REPEAT 443 481 Kelch 3.
 REPEAT 483 532 Kelch 4.
 REPEAT 542 588 Kelch 5.  

Keyword

 Complete proteome; Cytoplasm; Cytoskeleton; Golgi apparatus; Kelch repeat; Polymorphism; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 601 AA 

Protein Sequence

Gene Ontology

  

Interpro

 IPR011705; BACK.
 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR013069; BTB_POZ.
 IPR017096; Kelch-like_gigaxonin.
 IPR015915; Kelch-typ_b-propeller.
 IPR006652; Kelch_1. 

Pfam

 PF07707; BACK
 PF00651; BTB
 PF01344; Kelch_1 

SMART

 SM00875; BACK
 SM00225; BTB
 SM00612; Kelch 

PROSITE

 PS50097; BTB 

PRINTS