CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024060
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Paralemmin-1 
Protein Synonyms/Alias
 Paralemmin 
Gene Name
 Palm 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
147QTPLGTPKENRTSTPubiquitination[1]
315EDEAETKKVLGLQDTubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner. 
Sequence Annotation
 MOD_RES 108 108 Phosphoserine.
 MOD_RES 116 116 Phosphoserine (By similarity).
 MOD_RES 124 124 Phosphoserine (By similarity).
 MOD_RES 141 141 Phosphothreonine.
 MOD_RES 145 145 Phosphothreonine.
 MOD_RES 152 152 Phosphoserine.
 MOD_RES 157 157 Phosphoserine.
 MOD_RES 161 161 Phosphoserine (By similarity).
 MOD_RES 345 345 Phosphoserine.
 MOD_RES 363 363 Phosphothreonine.
 MOD_RES 365 365 Phosphoserine.
 MOD_RES 380 380 Cysteine methyl ester (Potential).
 LIPID 377 377 S-palmitoyl cysteine (Potential).
 LIPID 379 379 S-palmitoyl cysteine (Potential).
 LIPID 380 380 S-farnesyl cysteine (Potential).  
Keyword
 Alternative splicing; Cell membrane; Cell projection; Cell shape; Coiled coil; Complete proteome; Direct protein sequencing; Lipoprotein; Membrane; Methylation; Palmitate; Phosphoprotein; Prenylation; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 383 AA 
Protein Sequence
MEVLATDTAS QQERLQAIAE KRRKQAEIES KRRQLEDDRR QLQYLKSKAL RERWLLEGTP 60
SSASEGDEDM RKQMQEDEQK ARGLEESITR LEKEIDVLEF GESAPAASKE NSAAPSPGRP 120
QSASPAKEEQ KSETLVNAQQ TPLGTPKENR TSTPVRSPGG STMMKAAMYS VEITVEKDKV 180
TGETRVLSST TVLPRDPLPQ GVKVYEDETK VVHAVDGIAE NGIQPLSSSE VDELIHKADE 240
VTLSEAGSTA GPAEPRGLAE DVTRTTPSRR EITGVEAQPG EATSGPPGIQ PGQEPPVTMV 300
FMGYQNVEDE AETKKVLGLQ DTIKAELVVI EDAATPREPA PLNGSAAELP ATKEENQTGP 360
TTTPSDTQDL DMKKPRCRCC SVM 383 
Gene Ontology
 GO:0016327; C:apicolateral plasma membrane; IEA:UniProtKB-SubCell.
 GO:0030424; C:axon; IEA:UniProtKB-SubCell.
 GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0032590; C:dendrite membrane; IEA:Compara.
 GO:0032591; C:dendritic spine membrane; IEA:Compara.
 GO:0030175; C:filopodium; IDA:UniProtKB.
 GO:0031527; C:filopodium membrane; IEA:UniProtKB-SubCell.
 GO:0044309; C:neuron spine; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0071257; P:cellular response to electrical stimulus; IDA:UniProtKB.
 GO:0007010; P:cytoskeleton organization; IDA:MGI.
 GO:0007194; P:negative regulation of adenylate cyclase activity; IDA:MGI.
 GO:0060160; P:negative regulation of dopamine receptor signaling pathway; IEA:Compara.
 GO:0060999; P:positive regulation of dendritic spine development; IDA:UniProtKB.
 GO:0051491; P:positive regulation of filopodium assembly; IDA:UniProtKB.
 GO:0072661; P:protein targeting to plasma membrane; IDA:UniProtKB.
 GO:0008360; P:regulation of cell shape; IDA:MGI.
 GO:0060074; P:synapse maturation; IDA:UniProtKB. 
Interpro
 IPR004965; Paralemmin. 
Pfam
 PF03285; Paralemmin 
SMART
  
PROSITE
  
PRINTS