CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006899
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein arginine N-methyltransferase HSL7 
Protein Synonyms/Alias
  
Gene Name
 HSL7 
Gene Synonyms/Alias
 YBR133C; YBR1008 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
512SSPLFYQKLSQTNRSubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Involved in the control of the cell cycle at the G2/M (mitosis) transition. Cooperates with HSL1 to hyperphosphorylate SWE1, thereby targeting SWE1 for polyubiquitination and subsequent degradation. Acts as a negative regulator of the filamentous growth-signaling pathway through inhibition of STE20. 
Sequence Annotation
 MOD_RES 317 317 Phosphoserine.
 MOD_RES 614 614 Phosphothreonine.  
Keyword
 Cell cycle; Cell division; Complete proteome; Methyltransferase; Mitosis; Phosphoprotein; Reference proteome; S-adenosyl-L-methionine; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 827 AA 
Protein Sequence
MHSNVFVGVK PGFNHKQHSK KSRFLENVSS HSPELPSNYD YVLLPITTPR YKEIVGQVFK 60
DFQRQSIQNW KPLQIPEPQL QDICIPPFNV KKLDNDDTPS YIGLLSSWLE LESRDPNVRD 120
LGLKVLLNEC KYARFVGINK LILAPPRDLS NLQLYGQMIY RLLQNRIVFA APALTISISL 180
PLYEDSDPLA TWELWNTVRK QCEYHPSLTI SLALPRTRTP SYVLNRWLAE PVSCLLVSSS 240
IFASNQYDYP VLHKFNQNLI LKFQKVNGDS QILGNELCVI LHGMEKYANN VKGGESAYLE 300
YINYLLKKGD KVLNSNSNHQ FLLQEDSRIM PPLKPHSDNL LNSTYLTFEK DLVKYDLYES 360
AILEALQDLA PRASAKRPLV ILVAGAGRGP LVDRTFKIIS MLFMDSKVSI IAIEKNPQAY 420
LYLQKRNFDC WDNRVKLIKE DMTKWQINEP SEKRIQIDLC ISELLGSFGC NELSPECLWS 480
IEKYHSHNDT IFIPRSYSSY IAPISSPLFY QKLSQTNRSL EAPWIVHRVP YCILSSRVNE 540
VWRFEHPMAQ KDTVQDEDDF TVEFSQSSLN EFKIKHRGEI HGFIGFFSAN LYNNIFLSTL 600
PNDSTVRLKF SEETLMNTRR EENLIKKCDH TPNMTSWSPI IFPLKQPISF IDDSELSVLM 660
SRIHSDTEQK VWYEWSLESF IYLMLSNYTS AVTAASMTIP RSIVTDDTKT LAHNRHYSAT 720
TNQKLDNQID LDQDIENEEE QGFLSNLETG WQSVQDIHGL SETAKPDHLD SINKPMFDLK 780
STKALEPSNE LPRHEDLEED VPEVHVRVKT SVSTLHNVCG RAFSLPL 827 
Gene Ontology
 GO:0005935; C:cellular bud neck; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0042054; F:histone methyltransferase activity; IDA:UniProtKB.
 GO:0008469; F:histone-arginine N-methyltransferase activity; IEA:EC.
 GO:0035241; F:protein-arginine omega-N monomethyltransferase activity; IDA:SGD.
 GO:0035243; F:protein-arginine omega-N symmetric methyltransferase activity; IDA:SGD.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0000902; P:cell morphogenesis; IDA:UniProtKB.
 GO:0000086; P:G2/M transition of mitotic cell cycle; IMP:SGD.
 GO:0034969; P:histone arginine methylation; IEA:GOC.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0045840; P:positive regulation of mitosis; IDA:UniProtKB. 
Interpro
 IPR025799; Arg_MeTrfase.
 IPR007857; Arg_MeTrfase_PRMT5. 
Pfam
 PF05185; PRMT5 
SMART
  
PROSITE
  
PRINTS