CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014820
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 324B 
Protein Synonyms/Alias
  
Gene Name
 ZNF324B 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
65EPWVPSGKDMTLARNubiquitination[1]
214FGNASDLKAASGGRDubiquitination[1]
534RKVRRGGKPSPVLKPubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 DOMAIN 1 72 KRAB.
 ZN_FING 257 279 C2H2-type 1.
 ZN_FING 285 307 C2H2-type 2.
 ZN_FING 313 335 C2H2-type 3.
 ZN_FING 341 363 C2H2-type 4.
 ZN_FING 369 391 C2H2-type 5.
 ZN_FING 397 419 C2H2-type 6.
 ZN_FING 425 447 C2H2-type 7.
 ZN_FING 453 475 C2H2-type 8.
 ZN_FING 481 503 C2H2-type 9.  
Keyword
 Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 544 AA 
Protein Sequence
MTFEDVAVYF SQEEWGLLDT AQRALYRHVM LENFTLVTSL GLSTSRPRVV IQLERGEEPW 60
VPSGKDMTLA RNTYGRLNSG SWSLTEDRDV SGEWPRAFPD TPPGMTTSVF PVADACHSVK 120
SLQRQPGASP SQERKPTGVS VIYWERLLLG SRSDQASISL RLTSPLRPPK SSRPREKTFT 180
EYRVPGRQPR TPERQKPCAQ EVPGRAFGNA SDLKAASGGR DRRMGAAWQE PHRLLGGQEP 240
STWDELGEAL HAGEKSFECR ACSKVFVKSS DLLKHLRTHT GERPYECTQC GKAFSQTSHL 300
TQHQRIHSGE TPYACPVCGK AFRHSSSLVR HQRIHTAEKS FRCSECGKAF SHGSNLSQHR 360
KIHAGGRPYA CAQCGRRFCR NSHLIQHERT HTGEKPFVCA LCGAAFSQGS SLFLHQRVHT 420
GEKPFACAQC GRSFSRSSNL TQHQLLHTGE RPFRCVDCGK GFAKGAVLLS HRRIHTGEKP 480
FVCTQCGRAF RERPALLHHQ RIHTTEKTNA AAPDCTPGPG FLQGHHRKVR RGGKPSPVLK 540
PAKV 544 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01352; KRAB 
SMART
 SM00349; KRAB
 SM00355; ZnF_C2H2 
PROSITE
 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS