UniProt Accession

 ARL1_HUMAN; P40616; P80417; Q53XB1 

Genbank Protein ID

 L28997; AF493887; BT007260; AK311793; BX537387; CH471054; BC007000 

Genbank Nucleotide ID

 AAC37567.1; AAM12601.1; AAP35924.1; BAG34736.1; CAD97629.1; EAW97658.1; AAH07000.1 

Protein Name

 ADP-ribosylation factor-like protein 1 

Protein Synonyms/Alias

  

Gene Name

 ARL1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
59	NVETVTYKNLKFQVW	ubiquitination	[1]
62	TVTYKNLKFQVWDLG	ubiquitination	[2]
104	RDRIGISKSELVAML	ubiquitination	[1, 3]
149	SLGLPALKDRKWQIF	ubiquitination	[1]
152	LPALKDRKWQIFKTS	ubiquitination	[3]
157	DRKWQIFKTSATKGT	ubiquitination	[2, 3]
162	IFKTSATKGTGLDEA	ubiquitination	[3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus. 

Sequence Annotation

 NP_BIND 24 31 GTP.
 NP_BIND 45 48 GTP.
 NP_BIND 67 71 GTP (By similarity).
 NP_BIND 126 129 GTP.
 NP_BIND 160 161 GTP.
 METAL 31 31 Magnesium.
 METAL 48 48 Magnesium.
 BINDING 70 70 GTP; via amide nitrogen.
 LIPID 2 2 N-myristoyl glycine (By similarity).  

Keyword

 3D-structure; Complete proteome; Golgi apparatus; GTP-binding; Lipoprotein; Magnesium; Membrane; Metal-binding; Myristate; Nucleotide-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 181 AA 

Protein Sequence

Gene Ontology

 GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0005802; C:trans-Golgi network; ISS:UniProtKB.
 GO:0008047; F:enzyme activator activity; IDA:UniProtKB.
 GO:0005525; F:GTP binding; IDA:UniProtKB.
 GO:0003924; F:GTPase activity; IDA:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0031584; P:activation of phospholipase D activity; IDA:UniProtKB.
 GO:0007030; P:Golgi organization; ISS:UniProtKB.
 GO:0048193; P:Golgi vesicle transport; IEA:Compara.
 GO:0034067; P:protein localization to Golgi apparatus; IMP:UniProtKB.
 GO:0042147; P:retrograde transport, endosome to Golgi; IMP:UniProtKB.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
 GO:0009404; P:toxin metabolic process; IDA:UniProtKB. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR024156; Small_GTPase_ARF.
 IPR006689; Small_GTPase_ARF/SAR. 

Pfam

 PF00025; Arf 

SMART

 SM00177; ARF 

PROSITE

 PS51417; ARF 

PRINTS

 PR00328; SAR1GTPBP.