UniProt Accession

 V1AR_MOUSE; Q62463; Q62464; Q9QYH2 

Genbank Protein ID

 D49729; D49730; AB030013; BC024149 

Genbank Nucleotide ID

 BAA08566.1; BAA08567.1; BAA89050.1; AAH24149.1 

Protein Name

 Vasopressin V1a receptor 

Protein Synonyms/Alias

 V1aR; AVPR V1a; Antidiuretic hormone receptor 1a; Vascular/hepatic-type arginine vasopressin receptor 

Gene Name

 Avpr1a 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
285	TPCVSSVKSISRAKI	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Involved in social memory formation. 

Sequence Annotation

 MOD_RES 409 409 Phosphoserine.
 LIPID 370 370 S-palmitoyl cysteine (By similarity).
 LIPID 371 371 S-palmitoyl cysteine (By similarity).
 CARBOHYD 27 27 N-linked (GlcNAc...) (Potential).
 CARBOHYD 198 198 N-linked (GlcNAc...) (Potential).
 DISULFID 124 205 By similarity.  

Keyword

 Cell membrane; Complete proteome; Disulfide bond; G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Receptor; Reference proteome; Transducer; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 423 AA 

Protein Sequence

Gene Ontology

 GO:0031410; C:cytoplasmic vesicle; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0017046; F:peptide hormone binding; IEA:Compara.
 GO:0005000; F:vasopressin receptor activity; IEA:InterPro.
 GO:0019722; P:calcium-mediated signaling; IEA:Compara.
 GO:0042631; P:cellular response to water deprivation; IEA:Compara.
 GO:0007204; P:elevation of cytosolic calcium ion concentration; IEA:Compara.
 GO:0007625; P:grooming behavior; IEA:Compara.
 GO:0002125; P:maternal aggressive behavior; IEA:Compara.
 GO:0042711; P:maternal behavior; IEA:Compara.
 GO:0014902; P:myotube differentiation; IEA:Compara.
 GO:0007621; P:negative regulation of female receptivity; IEA:Compara.
 GO:0051970; P:negative regulation of transmission of nerve impulse; IEA:Compara.
 GO:0043084; P:penile erection; IEA:Compara.
 GO:0030307; P:positive regulation of cell growth; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0032849; P:positive regulation of cellular pH reduction; IEA:Compara.
 GO:0014049; P:positive regulation of glutamate secretion; IEA:Compara.
 GO:0010460; P:positive regulation of heart rate; IEA:Compara.
 GO:0031394; P:positive regulation of prostaglandin biosynthetic process; IEA:Compara.
 GO:0035815; P:positive regulation of renal sodium excretion; IEA:Compara.
 GO:0003084; P:positive regulation of systemic arterial blood pressure; IEA:Compara.
 GO:0045907; P:positive regulation of vasoconstriction; IEA:Compara.
 GO:0001992; P:regulation of systemic arterial blood pressure by vasopressin; IGI:MGI.
 GO:0051412; P:response to corticosterone stimulus; IEA:Compara.
 GO:0035176; P:social behavior; IEA:Compara.
 GO:0042713; P:sperm ejaculation; IEA:Compara.
 GO:0021537; P:telencephalon development; IEA:Compara. 

Interpro

 IPR015076; DUF1856.
 IPR000276; GPCR_Rhodpsn.
 IPR017452; GPCR_Rhodpsn_7TM.
 IPR001817; Vasoprsn_rcpt.
 IPR001224; Vprs_V1A_rcpt. 

Pfam

 PF00001; 7tm_1
 PF08983; DUF1856 

SMART

  

PROSITE

 PS00237; G_PROTEIN_RECEP_F1_1
 PS50262; G_PROTEIN_RECEP_F1_2 

PRINTS

 PR00237; GPCRRHODOPSN.
 PR00896; VASOPRESSINR.
 PR00752; VASOPRSNV1AR.