CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013940
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 678 
Protein Synonyms/Alias
  
Gene Name
 ZNF678 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
68LDNLHLVKDWRTVNEubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 ZN_FING 97 119 C2H2-type 1.
 ZN_FING 125 147 C2H2-type 2.
 ZN_FING 153 175 C2H2-type 3.
 ZN_FING 181 203 C2H2-type 4.
 ZN_FING 209 231 C2H2-type 5.
 ZN_FING 237 259 C2H2-type 6.
 ZN_FING 265 287 C2H2-type 7.
 ZN_FING 293 315 C2H2-type 8.
 ZN_FING 321 343 C2H2-type 9.
 ZN_FING 349 371 C2H2-type 10.
 ZN_FING 377 399 C2H2-type 11.
 ZN_FING 405 427 C2H2-type 12.
 ZN_FING 433 455 C2H2-type 13.
 ZN_FING 461 483 C2H2-type 14.
 ZN_FING 489 511 C2H2-type 15; degenerate.  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 525 AA 
Protein Sequence
MGTISLCIGV CAFEGANTST SFYKLVYTAI LSYSIQDLLP EQDMKDLCQK VTLTRHRSWG 60
LDNLHLVKDW RTVNEGKGQK EYCNRLTQCS STKSKIFQCI ECGRNFSWRS ILTEHKRIHT 120
GEKPYKCEEC GKVFNRCSNL TKHKRIHTGE KPYKCDECGK VFNWWSQLTN HKKIHTGEKP 180
YKCDECDKVF NWWSQLTSHK KIHSGEKPYP CEECGKAFTQ FSNLTQHKRI HTGEKPYKCK 240
ECCKAFNKFS NLTQHKRIHT GEKPYKCEEC GNVFNECSHL TRHRRIHTGE KPYKCEECGK 300
AFTQFASLTR HKRIHTGEKP YQCEECGKTF NRCSHLSSHK RIHTGEKPYK CEECGRTFTQ 360
FSNLTQHKRI HTGEKPYKCK ECGKAFNKFS SLTQHRRIHT GVKPYKCEEC GKVFKQCSHL 420
TSHKRIHTGE KPYKCKECGK AFYQSSILSK HKRIHTEEKP YKCEECGKAF NQFSSLTRHK 480
RIHTGEKRYK CKECGKGFYQ SSIHSKYKRI YTGEEPDKCK KCGSL 525 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
  
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS