CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010691
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Acidic leucine-rich nuclear phosphoprotein 32 family member E 
Protein Synonyms/Alias
 Cerebellar postnatal development protein 1; LANP-like protein; LANP-L 
Gene Name
 Anp32e 
Gene Synonyms/Alias
 Cpd1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
65ARLPSLNKLRKLELSubiquitination[1]
68PSLNKLRKLELSDNIubiquitination[1]
99YLNLSGNKIKDLSTVubiquitination[1]
101NLSGNKIKDLSTVEAubiquitination[1]
113VEALQNLKNLKSLDLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis process by modulating PP2A activity. 
Sequence Annotation
 REPEAT 18 38 LRR 1.
 REPEAT 43 64 LRR 2.
 REPEAT 65 87 LRR 3.
 REPEAT 89 110 LRR 4.
 DOMAIN 123 161 LRRCT.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Leucine-rich repeat; Nucleus; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 260 AA 
Protein Sequence
MEMKKKINME LKNRAPEEVT ELVLDNCLCV NGEIEGLNDT FKELEFLSMA NVELSSLARL 60
PSLNKLRKLE LSDNIISGGL EVLAEKCPNL TYLNLSGNKI KDLSTVEALQ NLKNLKSLDL 120
FNCEITNLED YRESIFELLQ QITYLDGFDQ EDNEAPDSEE EDDDDEDGDE DEEDEDEDEA 180
GPPEGYEEEE DDDEDEAGSE VGEGEEEVGL SYLMKDEIQD EEDDDDYVDE GEEEEEEEEE 240
GLRGEKRKRD AEDDGEEDDD 260 
Gene Ontology
 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0019212; F:phosphatase inhibitor activity; IDA:MGI. 
Interpro
 IPR001611; Leu-rich_rpt.
 IPR025875; Leu-rich_rpt_4.
 IPR003603; U2A'_phosphoprotein32A_C. 
Pfam
 PF12799; LRR_4 
SMART
 SM00446; LRRcap 
PROSITE
 PS51450; LRR 
PRINTS