| Tag | Content |
|---|
| CPLM ID | CPLM-020673 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Renin receptor |
Protein Synonyms/Alias | ATPase H(+)-transporting lysosomal accessory protein 2; ATPase H(+)-transporting lysosomal-interacting protein 2; Renin/prorenin receptor |
Gene Name | Atp6ap2 |
Gene Synonyms/Alias | Atp6ip2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 346 | IYRMTNQKIRID*** | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS) (By similarity). |
Sequence Annotation | |
Keyword | Complete proteome; Membrane; Phosphoprotein; Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 350 AA |
Protein Sequence | MAVLVVLLFF LVAGALGNEF SILRSPGSVV FRNGNWPIPG DRIPDVAALS MGFSVKEDLS 60
WPGLAVGNLF HRPRATIMVM VKGVDKLALP AGSVISYPLE NAVPFSLDSV ANSIHSLFSE 120
ETPVVLQLAP SEERVYMVGK ANSVFEDLSV TLRQLRNRLF QENSLLNSLP LNSLSRNNEV 180
DLLFLSELQV LHDISSLLSR HKHLAKDHSP DLYSLELAGL DELGKRYGED SEQFRDASKI 240
LVDALQKFAD DMYSLYGGNA VVELVTVKSF DTSLVRKSRT ILEAKQENTQ SPYNLAYKYN 300
LEYSVVFNLV LWIMIGLALA VIITSYNIWN MDPGYDSIIY RMTNQKIRID 350 |
Gene Ontology | GO:0044297; C:cell body; IEA:Compara. GO:0009897; C:external side of plasma membrane; IEA:Compara. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0043005; C:neuron projection; IEA:Compara. GO:0004872; F:receptor activity; IEA:InterPro. GO:0002003; P:angiotensin maturation; IEA:Compara. GO:0032914; P:positive regulation of transforming growth factor beta1 production; IEA:Compara. GO:0043408; P:regulation of MAPK cascade; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |