CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015779
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 EPM2A-interacting protein 1 
Protein Synonyms/Alias
 Laforin-interacting protein 
Gene Name
 EPM2AIP1 
Gene Synonyms/Alias
 KIAA0766; My007 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
111LCRLLALKGRGWGEGubiquitination[1]
469MVICRLQKEFERHFKacetylation[2]
495FSNPFNFKPEYAPISubiquitination[3, 4, 5]
523LWNEYRIKDLGQFYAubiquitination[3, 5]
559DSNQICEKAFSYLTRubiquitination[1, 6]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [6] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572
Functional Description
  
Sequence Annotation
 MOD_RES 146 146 Phosphoserine.  
Keyword
 Complete proteome; Endoplasmic reticulum; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 607 AA 
Protein Sequence
MWMTPKRSKM EVDEALVFRP EWTQRYLVVE PPEGDGALCL VCRRLIVATR ERDVRRHYEA 60
EHEYYERYVA DGERAALVER LRQGDLPVAS FTPEERAARA GLGLCRLLAL KGRGWGEGDF 120
VYQCMEVLLR EVLPEHVSVL QGVDLSPDIT RQRILSIDRN LRNQLFNRAR DFKAYSLALD 180
DQAFVAYENY LLVFIRGVGP ELEVQEDLLT IINLTHHFSV GALMSAILES LQTAGLSLQR 240
MVGLTTTHTL RMIGENSGLV SYMREKAVSP NCWNVIHYSG FLHLELLSSY DVDVNQIINT 300
ISEWIVLIKT RGVRRPEFQT LLTESESEHG ERVNGRCLNN WLRRGKTLKL IFSLRKEMEA 360
FLVSVGATTV HFSDKQWLCD FGFLVDIMEH LRELSEELRV SKVFAAAAFD HICTFEVKLN 420
LFQRHIEEKN LTDFPALREV VDELKQQNKE DEKIFDPDRY QMVICRLQKE FERHFKDLRF 480
IKKDLELFSN PFNFKPEYAP ISVRVELTKL QANTNLWNEY RIKDLGQFYA GLSAESYPII 540
KGVACKVASL FDSNQICEKA FSYLTRNQHT LSQPLTDEHL QALFRVATTE MEPGWDDLVR 600
ERNESNP 607 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell. 
Interpro
 IPR026630; EPM2A-int_1. 
Pfam
  
SMART
  
PROSITE
  
PRINTS