CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028401
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ral GTPase-activating protein subunit beta 
Protein Synonyms/Alias
  
Gene Name
 RALGAPB 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
221PPYWKTAKEMVANWRubiquitination[1]
999RGAKANQKLFVPEPRubiquitination[2]
1176KTNQEILKNVESSRTubiquitination[1, 2, 3]
1466KITDIVNKYRNKQLEubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1491 AA 
Protein Sequence
MYSEWRSLHL VIQNDQGHTS VLHSYPESVG REVANAVVRP LGQVLGTPSV AGSENLLKTD 60
KEVKWTMEVI CYGLTLPLDG ETVKYCVDVY TDWIMALVLP KDSIPLPVIK EPNQYVQTIL 120
KHLQNLFVPR QEQGSSQIRL CLQVLRAIQK LARESSLMAR ETWEVLLLFL LQINDILLAP 180
PTVQGGIAEN LAEKLIGVLF EVWLLACTRC FPTPPYWKTA KEMVANWRHH PAVVEQWSKV 240
ICALTSRLLR FTYGPSFPAF KVPDEDASLI PPEMDNECVA QTWFRFLHML SNPVDLSNPA 300
IISSTPKFQE QFLNVSGMPQ ELNQYPCLKH LPQIFFRAMR GISCLVDAFL GISRPRSDSA 360
PPTPVNRLSM PQSAAVSTTP PHNRRHRAVT VNKATMKTST VSTAHASKVQ HQTSSTSPLS 420
SPNQTSSEPR PLPAPRRPKV NSILNLFGSW LFDAAFVHCK LHNGINRDSS MTAITTQASM 480
EFRRKGSQMS TDTMVSNPMF DASEFPDNYE AGRAEACGTL CRIFCSKKTG EEILPAYLSR 540
FYMLLIQGLQ INDYVCHPVL ASVILNSPPL FCCDLKGIDV VVPYFISALE TILPDRELSK 600
FKSYVNPTEL RRSSINILLS LLPLPHHFGT VKSEVVLEGK FSNDDSSSYD KPITFLSLKL 660
RLVNILIGAL QTETDPNNTQ MILGAMLNIV QDSALLEAIG CQMEMGGGEN NLKSHSRTNS 720
GISSASGGST EPTTPDSERP AQALLRDYDS AAGLLIRSIH LVTQRLNSQW RQDMSISLAA 780
LELLSGLAKV KVMVDSGDRK RAISSVCTYI VYQCSRPAPL HSRDLHSMIV AAFQCLCVWL 840
TEHPDMLDEK DCLKEVLEIV ELGISGSKSK NNEQEVKYKG DKEPNPASMR VKDAAEATLT 900
CIMQLLGAFP SPSGPASPCS LVNETTLIKY SRLPTINKHS FRYFVLDNSV ILAMLEQPLG 960
NEQNDFFPSV TVLVRGMSGR LAWAQQLCLL PRGAKANQKL FVPEPRPVPK NDVGFKYSVK 1020
HRPFPEEVDK IPFVKADLSI PDLHEIVTEE LEERHEKLRS GMAQQIAYEI HLEQQSEEEL 1080
QKRSFPDPVT DCKPPPPAQE FQTARLFLSH FGFLSLEALK EPANSRLPPH LIALDSTIPG 1140
FFDDIGYLDL LPCRPFDTVF IFYMKPGQKT NQEILKNVES SRTVQPHFLE FLLSLGWSVD 1200
VGRHPGWTGH VSTSWSINCC DDGEGSQQEE VISSEDIGAS IFNGQKKVLY YADALTEIAF 1260
VVPSPVESLT DSLESNISDQ DSDSNMDLMP GILKQPSLTL ELFPNHTDNL NSSQRLSPSS 1320
RMRKLPQGRP VPPLGPETRV SVVWVERYDD IENFPLSELM TEISTGVETT ANSSTSLRST 1380
TLEKEVPVIF IHPLNTGLFR IKIQGATGKF NMVIPLVDGM IVSRRALGFL VRQTVINICR 1440
RKRLESDSYS PPHVRRKQKI TDIVNKYRNK QLEPEFYTSL FQEVGLKNCS S 1491 
Gene Ontology
 GO:0005096; F:GTPase activator activity; IEA:InterPro.
 GO:0043547; P:positive regulation of GTPase activity; IEA:GOC.
 GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR000331; Rap_GAP_dom. 
Pfam
  
SMART
  
PROSITE
 PS50085; RAPGAP 
PRINTS