CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037740
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Tyrosine-protein phosphatase non-receptor type 22 
Protein Synonyms/Alias
  
Gene Name
 PTPN22 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
17FLDEAQSKKITKEEFubiquitination[1]
18LDEAQSKKITKEEFAubiquitination[1]
21AQSKKITKEEFANEFubiquitination[1]
32ANEFLKLKRQSTKYKubiquitination[1]
61NIKKNRYKDILPYDYubiquitination[1]
166SCEAEKRKSDYIIRTubiquitination[1]
260AKHCIPEKNHTLQADubiquitination[1, 2, 3]
309RTSEISAKEELVLHPubiquitination[1]
341KNADTTMKWQTKAFPubiquitination[1, 3]
345TTMKWQTKAFPIVGEubiquitination[1, 2, 3]
356IVGEPLQKHQSLDLGubiquitination[1]
374FEGCSNSKPVNAAGRubiquitination[1, 3]
386AGRYFNSKVPITRTKubiquitination[1, 3]
393KVPITRTKSTPFELIubiquitination[1, 2, 3]
406LIQQRETKEVDSKENubiquitination[1]
411ETKEVDSKENFSYLEubiquitination[1, 3]
451YSLPYDSKHQIRNASubiquitination[1, 3]
585EFSPNVPKSLSSAVKubiquitination[1]
592KSLSSAVKVKIGTSLubiquitination[1]
594LSSAVKVKIGTSLEWubiquitination[1]
609GGTSEPKKFDDSVILubiquitination[1]
715CNSCPPNKPAESVQSubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Protein phosphatase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 752 AA 
Protein Sequence
MDQREILQKF LDEAQSKKIT KEEFANEFLK LKRQSTKYKA DKTYPTTVAE KPKNIKKNRY 60
KDILPYDYSR VELSLITSDE DSSYINANFI KGVYGPKAYI ATQGPLSTTL LDFWRMIWEY 120
SVLIIVMACM EYEMGKKKCE RYWAEPGEMQ LEFGPFSVSC EAEKRKSDYI IRTLKVKFNS 180
ETRTIYQFHY KNWPDHDVPS SIDPILELIW DVRCYQEDDS VPICIHCSAG CGRTGVICAI 240
DYTWMLLKDG SQAKHCIPEK NHTLQADSYS PNLPKSTTKA AKMMNQQRTK MEIKESSSFD 300
FRTSEISAKE ELVLHPAKSS TSFDFLELNY SFDKNADTTM KWQTKAFPIV GEPLQKHQSL 360
DLGSLLFEGC SNSKPVNAAG RYFNSKVPIT RTKSTPFELI QQRETKEVDS KENFSYLESQ 420
PHDSCFVEMQ AQKVMHVSSA ELNYSLPYDS KHQIRNASNV KHHDSSALGV YSYIPLVENP 480
YFSSWPPSGT SSKMSLDLPE KQDGTVFPSS LLPTSSTSLF SYYNSHDSLS LNSPTNISSL 540
LNQESAVLAT APRIDDEIPP PLPVWTPESF IVVEEAGEFS PNVPKSLSSA VKVKIGTSLE 600
WGGTSEPKKF DDSVILRPSK SVKLRSPKSE LHQDRSSPPP PLPERTLESF FLADEDCMQA 660
QSIETYSTSY PDTMENSTSS KQTLKTPGKS FTRSKSLKIL RNMKKSICNS CPPNKPAESV 720
QSNNSSSFLN FGFANRFSKP KGPRNPPPTW NI 752 
Gene Ontology
 GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
 GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC. 
Interpro
 IPR000387; Tyr/Dual-sp_Pase.
 IPR016130; Tyr_Pase_AS.
 IPR000242; Tyr_Pase_rcpt/non-rcpt. 
Pfam
 PF00102; Y_phosphatase 
SMART
 SM00194; PTPc 
PROSITE
 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2
 PS50055; TYR_PHOSPHATASE_PTP 
PRINTS
 PR00700; PRTYPHPHTASE.