CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018010
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Up-regulator of cell proliferation 
Protein Synonyms/Alias
 HBV X protein up-regulated gene 4 protein; HBxAg up-regulated gene 4 protein 
Gene Name
 URGCP 
Gene Synonyms/Alias
 KIAA1507; URG4 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
121LPWNFLRKLQALNADubiquitination[1]
275MDVSSNSKSQLLNAVubiquitination[1, 2, 3, 4]
371NISKKEYKLLYSMKEmethylation[5]
403TNLRFLNKLIPVLKIubiquitination[1, 4]
429TDSDSFVKRIRAIVGubiquitination[1, 2, 4]
457DMAHAARKLGLKVDEubiquitination[1]
461AARKLGLKVDEDCEEubiquitination[1]
563SSPSLSEKQYFLRWMubiquitination[1, 3]
680RWVTGLLKELHVRLEubiquitination[1]
721GLRFATGKSCGPRGAubiquitination[1]
854RAAAQMEKQGDGFRAubiquitination[1, 2, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510] 
Functional Description
 May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in the development of hepatocellular carcinoma (HCC) by promoting hepatocellular growth and survival. May play an important role in development of gastric cancer. 
Sequence Annotation
  
Keyword
 Alternative splicing; Cell cycle; Complete proteome; Cytoplasm; Nucleus; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 931 AA 
Protein Sequence
MASPGIEVEL LGKGHSDLGE VAPEIKASER RTAVAIADLE WREMEGDDCE FRYGDGTNEA 60
QDNDFPTVER SRLQEMLSLL GLETYQVQKL SLQDSLQISF DSMKNWAPQV PKDLPWNFLR 120
KLQALNADAR NTTMVLDVLP DARPVEKESQ MEEEIIYWDP ADDLAADIYS FSELPTPDTP 180
VNPLDLLCAL LLSSDSFLQQ EIALKMALCQ FALPLVLPDS ENHYHTFLLW AMRGIVRTWW 240
SQPPRGMGSF REDSVVLSRA PAFAFVRMDV SSNSKSQLLN AVLSPGHRQW DCFWHRDLNL 300
GTNAREISDG LVEISWFFPS GREDLDIFPE PVAFLNLRGD IGSHWLQFKL LTEISSAVFI 360
LTDNISKKEY KLLYSMKEST TKYYFILSPY RGKRNTNLRF LNKLIPVLKI DHSHVLVKVS 420
STDSDSFVKR IRAIVGNVLR APCRRVSVED MAHAARKLGL KVDEDCEECQ KAKDRMERIT 480
RKIKDSDAYR RDELRLQGDP WRKAAQVEKE FCQLQWAVDP PEKHRAELRR RLLELRMQQN 540
GHDPSSGVQE FISGISSPSL SEKQYFLRWM EWGLARVAQP RLRQPPETLL TLRPKHGGTT 600
DVGEPLWPEP LGVEHFLREM GQFYEAESCL VEAGRLPAGQ RRFAHFPGLA SELLLTGLPL 660
ELIDGSTLSM PVRWVTGLLK ELHVRLERRS RLVVLSTVGV PGTGKSTLLN TMFGLRFATG 720
KSCGPRGAFM QLITVAEGFS QDLGCDHILV IDSGGLIGGA LTSAGDRFEL EASLATLLMG 780
LSNVTVISLA ETKDIPAAIL HAFLRLEKTG HMPNYQFVYQ NLHDVSVPGP RPRDKRQLLD 840
PPGDLSRAAA QMEKQGDGFR ALAGLAFCDP EKQHIWHIPG LWHGAPPMAA VSLAYSEAIF 900
ELKRCLLENI RNGLSNQNKN IQQLIELVRR L 931 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005525; F:GTP binding; IEA:InterPro.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW. 
Interpro
 IPR006073; GTP_binding_domain.
 IPR027417; P-loop_NTPase. 
Pfam
  
SMART
  
PROSITE
  
PRINTS
 PR00326; GTP1OBG.