CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001681
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein SNAI1 
Protein Synonyms/Alias
 Protein snail homolog 1; Protein sna 
Gene Name
 SNAI1 
Gene Synonyms/Alias
 SNAH 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
98LSDEDSGKGSQPPSPubiquitination[1]
137PGLGQVPKQLAQLSEubiquitination[1]
146LAQLSEAKDLQARKAubiquitination[1]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up- regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself. 
Sequence Annotation
 ZN_FING 154 176 C2H2-type 1.
 ZN_FING 178 202 C2H2-type 2.
 ZN_FING 208 230 C2H2-type 3.
 ZN_FING 236 259 C2H2-type 4; atypical.
 REGION 1 20 SNAG domain (By similarity).
 REGION 10 40 LATS2 binding.
 REGION 120 151 Required for FBXL14-triggered
 REGION 151 264 Required for nuclear localization and
 MOTIF 95 100 Destruction motif.
 MOD_RES 11 11 Phosphoserine; by PKA.
 MOD_RES 82 82 Phosphoserine.
 MOD_RES 92 92 Phosphoserine; by CK2.
 MOD_RES 96 96 Phosphoserine.
 MOD_RES 100 100 Phosphoserine (Probable).
 MOD_RES 104 104 Phosphoserine.
 MOD_RES 107 107 Phosphoserine.
 MOD_RES 111 111 Phosphoserine (Probable).
 MOD_RES 115 115 Phosphoserine (Probable).
 MOD_RES 119 119 Phosphoserine (Probable).
 MOD_RES 203 203 Phosphothreonine; by LATS2.
 MOD_RES 246 246 Phosphoserine; by PAK1.
 CARBOHYD 112 112 O-linked (GlcNAc...).
 CROSSLNK 98 98 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 137 137 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 146 146 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 3D-structure; ADP-ribosylation; Complete proteome; Cytoplasm; Developmental protein; DNA-binding; Glycoprotein; Isopeptide bond; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Ubl conjugation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 264 AA 
Protein Sequence
MPRSFLVRKP SDPNRKPNYS ELQDSNPEFT FQQPYDQAHL LAAIPPPEIL NPTASLPMLI 60
WDSVLAPQAQ PIAWASLRLQ ESPRVAELTS LSDEDSGKGS QPPSPPSPAP SSFSSTSVSS 120
LEAEAYAAFP GLGQVPKQLA QLSEAKDLQA RKAFNCKYCN KEYLSLGALK MHIRSHTLPC 180
VCGTCGKAFS RPWLLQGHVR THTGEKPFSC PHCSRAFADR SNLRAHLQTH SDVKKYQCQA 240
CARTFSRMSL LHKHQESGCS GCPR 264 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0001078; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; IDA:BHF-UCL.
 GO:0043565; F:sequence-specific DNA binding; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0060536; P:cartilage morphogenesis; IEA:Compara.
 GO:0016477; P:cell migration; IEA:Compara.
 GO:0001837; P:epithelial to mesenchymal transition; IDA:UniProtKB.
 GO:0031069; P:hair follicle morphogenesis; IEA:Compara.
 GO:0060972; P:left/right pattern formation; IEA:Compara.
 GO:0001707; P:mesoderm formation; ISS:UniProtKB.
 GO:0043066; P:negative regulation of apoptotic process; IMP:BHF-UCL.
 GO:0060806; P:negative regulation of cell differentiation involved in embryonic placenta development; IEA:Compara.
 GO:0043518; P:negative regulation of DNA damage response, signal transduction by p53 class mediator; IMP:BHF-UCL.
 GO:0010957; P:negative regulation of vitamin D biosynthetic process; IDA:BHF-UCL.
 GO:0061314; P:Notch signaling involved in heart development; ISS:BHF-UCL.
 GO:0001649; P:osteoblast differentiation; IEP:UniProtKB.
 GO:0060021; P:palate development; IEA:Compara.
 GO:0030335; P:positive regulation of cell migration; IMP:UniProtKB.
 GO:0010718; P:positive regulation of epithelial to mesenchymal transition; IMP:UniProtKB.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IMP:UniProtKB.
 GO:2000810; P:regulation of tight junction assembly; IMP:BHF-UCL.
 GO:0060707; P:trophoblast giant cell differentiation; IEA:Compara. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
  
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS